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Samotolisib

CAT: 0013-GTR19167989-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167989-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Samotolisib (LY3023414) is an orally bioavailable, ATP-competitive inhibitor targeting class I PI3K isoforms, DNA-PK, and mTOR. It has been investigated in preclinical and clinical studies for various solid tumors, including advanced breast and colon cancers, demonstrating research utility in both in vitro and in vivo models.
CAS Number
1386874-06-1
Product Name Alternative
Autophagy, DNA-dependent protein kinase, DNAPK, DNA-PK, class I PI3K isoforms, Mammalian target of Rapamycin, GTPL 8918, GTPL8918, GTPL-8918, Inhibitor, inhibit, mTOR kinase, mTOR, LY 3023414, LY3023414, LY-3023414, PI3K, Phosphoinositide 3-kinase, Samotolisib
Field of Research
Cell Biology, Molecular Biology, Signal Transduction
Purity
98.41% (May vary between batches)
Solubility
H2O:< 1 mg/mL (insoluble or slightly soluble) ; Ethanol:57 mg/mL (140.23 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.92 mM) ; DMSO:50 mg/mL (123.01 mM)
Smiles
COC (C) Cn1c2c (cnc3ccc (cc23) -c2cncc (c2) C (C) (C) O) n (C) c1=O
Molecular Formula
C23H26N4O3
Molecular Weight
406.48
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Samotolisib

LY3023414 has been used in trials studying the treatment of Neoplasm, Solid Tumor, COLON CANCER, BREAST CANCER, and Advanced Cancer, among others.

CAS Number1386874-06-1
PubChem CID57519748
IUPAC Name8-[5-(2-hydroxypropan-2-yl)-3-pyridinyl]-1-[(2S)-2-methoxypropyl]-3-methylimidazo[4,5-c]quinolin-2-one
Molecular FormulaC23H26N4O3
Molecular Weight406.5
XLogP1.7
Topological Polar Surface Area78.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity630
SMILES
C[C@@H](CN1C2=C3C=C(C=CC3=NC=C2N(C1=O)C)C4=CC(=CN=C4)C(C)(C)O)OC
InChI
InChI=1S/C23H26N4O3/c1-14(30-5)13-27-21-18-9-15(16-8-17(11-24-10-16)23(2,3)29)6-7-19(18)25-12-20(21)26(4)22(27)28/h6-12,14,29H,13H2,1-5H3/t14-/m0/s1
InChIKey
ACCFLVVUVBJNGT-AWEZNQCLSA-N
Chemical Structure
2D Structure
2D structure of Samotolisib
CAS: 1386874-06-1
CID: 57519748
Formula: C23H26N4O3
MW: 406.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight406.5
XLogP31.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass406.20049070
Monoisotopic Mass406.20049070
Topological Polar Surface Area78.8 Ų
Heavy Atom Count30
Formal Charge0
Complexity630
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
206214Samotolisib
C13343-5mgSamotolisib (LY3023414)

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