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PLX7904

CAT: 0013-GTR19167927-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167927-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PLX7904 (PB04) is a selective paradox-breaker RAF inhibitor that suppresses ERK1/2 signaling in BRAF-mutant melanoma cells without inducing paradoxical activation in RAS-mutant contexts. Its profile supports its use in vitro and in vivo for investigating targeted therapies in oncology, particularly for overcoming resistance mechanisms in MAPK pathway-driven cancers.
CAS Number
1393465-84-3
Product Name Alternative
B-Raf (V600E), Inhibitor, inhibit, PB 04, PB04, PB-04, PLX7904, PLX-7904, PLX 7904, Raf, Raf kinases
Field of Research
Signal Transduction
Purity
96.27% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.8 mM) ; H2O:< 1 mg/mL (insoluble or slightly soluble) ; DMSO:100 mg/mL (195.11 mM) ; Ethanol:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CCN (C) S (=O) (=O) Nc1ccc (F) c (C (=O) c2c[nH]c3ncc (cc23) -c2cnc (nc2) C2CC2) c1F
Molecular Formula
C24H22F2N6O3S
Molecular Weight
512.53
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
B6177-100PLX7904
A15855-100PLX7904 100mg
A15855-50PLX7904 50mg
A15855-25PLX7904 25mg
A15855-5PLX7904 5mg
A15855-10PLX7904 10mg
A15855-10mM-DPLX7904 10mM * 1mL in DMSO

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