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LY2828360

CAT: 0013-GTR19167719-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167719-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY2828360 is a potent and selective cannabinoid receptor 2 (CB2) agonist with a Ki of 40.3 nM. It demonstrates high functional selectivity for CB2 over CB1 (EC50 = 20.1 nM vs. >100,000 nM) . This compound is a valuable research tool for studying CB2 receptor function in immunological and neurological contexts, both in vitro and in vivo.
CAS Number
1231220-79-3
Product Name Alternative
CB, Cannabinoid Receptor, CannabinoidReceptor, inhibit, Inhibitor, LY2828360, LY-2828360, LY 2828360
Field of Research
Pharmacology & Drug Discovery
Purity
98.45% (May vary between batches)
Solubility
DMSO:1 mg/mL (2.34 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.34 mM)
Smiles
CN1CCN (CC1) c1nc (C) nc2n (C3CCOCC3) c (nc12) -c1ccccc1Cl
Molecular Formula
C22H27ClN6O
Molecular Weight
426.94
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Ly2828360

LY2828360 is under investigation in clinical trial NCT01319929 (A Study of LY2828360 in Patients With Osteoarthritic Knee Pain).

CAS Number1231220-79-3
PubChem CID46833780
IUPAC Name8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)purine
Molecular FormulaC22H27ClN6O
Molecular Weight426.9
XLogP3.3
Topological Polar Surface Area59.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count30
Formal Charge0
Complexity570
SMILES
CC1=NC2=C(C(=N1)N3CCN(CC3)C)N=C(N2C4CCOCC4)C5=CC=CC=C5Cl
InChI
InChI=1S/C22H27ClN6O/c1-15-24-21(28-11-9-27(2)10-12-28)19-22(25-15)29(16-7-13-30-14-8-16)20(26-19)17-5-3-4-6-18(17)23/h3-6,16H,7-14H2,1-2H3
InChIKey
UCMNDPDJRSEZPL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ly2828360
CAS: 1231220-79-3
CID: 46833780
Formula: C22H27ClN6O
MW: 426.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight426.9
XLogP33.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass426.1934872
Monoisotopic Mass426.1934872
Topological Polar Surface Area59.3 Ų
Heavy Atom Count30
Formal Charge0
Complexity570
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
MBS3610694-01LY2828360
A22228-100LY2828360 100mg
A22228-5LY2828360 5mg
A22228-50LY2828360 50mg
A22228-10LY2828360 10mg
A22228-25LY2828360 25mg
A22228-2LY2828360 2mg

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