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Angiotensin II human

CAT: 0013-GTR19168068-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19168068-01Size:5 mg
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Description
Angiotensin II is a key vasoactive peptide that elevates blood pressure via AT1R and AT2R receptors, driving vasoconstriction, aldosterone release, and cellular remodeling. It is extensively used in research to establish in vivo models of hypertension and cardiac hypertrophy and for in vitro studies of vascular smooth muscle and endothelial cell function.
CAS Number
4474-91-3
Product Name Alternative
DRVYIHPF, Angiotensin Receptor, Ang II, Angiotensin II human, Angiotensin II, Apoptosis, AT receptor, inhibit, Inhibitor, Hypertensin II
Field of Research
Cell Biology, Metabolism Research, Pharmacology & Drug Discovery
Purity
95.00% (May vary between batches)
Solubility
H2O:10.52 mg/mL (10.06 mM) ; DMSO:< 1 mg/mL (insoluble)
Smiles
CCC (C) C (NC (=O) C (Cc1ccc (O) cc1) NC (=O) C (NC (=O) C (CCCN=C (N) N) NC (=O) C (N) CC (O) =O) C (C) C) C (=O) NC (Cc1cnc[nH]1) C (=O) N1CCCC1C (=O) NC (Cc1ccccc1) C (O) =O
Molecular Formula
C50H71N13O12
Molecular Weight
1046.18
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Angiotensin Ii

Ile(5)-angiotensin II is an angiotensin II that acts on the central nervous system (PDB entry: 1N9V). It has a role as a human metabolite. It is a tautomer of an Ile(5)-angiotensin II dizwitterion.

CAS Number4474-91-3
PubChem CID172198
IUPAC Name(3S)-3-amino-4-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[(2S)-2-[[(1S)-1-carboxy-2-phenylethyl]carbamoyl]pyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
Molecular FormulaC50H71N13O12
Molecular Weight1046.2
XLogP-1.7
Topological Polar Surface Area409
Hydrogen Bond Donor Count13
Hydrogen Bond Acceptor Count15
Rotatable Bond Count29
Heavy Atom Count75
Formal Charge0
Complexity1980
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(=O)O)N
InChI
InChI=1S/C50H71N13O12/c1-5-28(4)41(47(72)59-36(23-31-25-54-26-56-31)48(73)63-20-10-14-38(63)45(70)60-37(49(74)75)22-29-11-7-6-8-12-29)62-44(69)35(21-30-15-17-32(64)18-16-30)58-46(71)40(27(2)3)61-43(68)34(13-9-19-55-50(52)53)57-42(67)33(51)24-39(65)66/h6-8,11-12,15-18,25-28,33-38,40-41,64H,5,9-10,13-14,19-24,51H2,1-4H3,(H,54,56)(H,57,67)(H,58,71)(H,59,72)(H,60,70)(H,61,68)(H,62,69)(H,65,66)(H,74,75)(H4,52,53,55)/t28-,33-,34-,35-,36-,37-,38-,40-,41-/m0/s1
InChIKey
CZGUSIXMZVURDU-JZXHSEFVSA-N
Chemical Structure
2D Structure
2D structure of Angiotensin Ii
CAS: 4474-91-3
CID: 172198
Formula: C50H71N13O12
MW: 1046.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1046.2
XLogP3-1.7
Hydrogen Bond Donor Count13
Hydrogen Bond Acceptor Count15
Rotatable Bond Count29
Exact Mass1045.53451475
Monoisotopic Mass1045.53451475
Topological Polar Surface Area409 Ų
Heavy Atom Count75
Formal Charge0
Complexity1980
Isotope Atom Count0
Defined Atom Stereocenter Count9
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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