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Donepezil

CAT: 0013-GTR19168057-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19168057-02Size:1 ml x 10 mM (in DMSO)
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Description
Donepezil is a selective, reversible acetylcholinesterase inhibitor of the piperidine class. It is widely used in neuroscience research to study cholinergic neurotransmission and is a standard therapeutic agent in models of Alzheimer's disease, both in vitro and in vivo.
CAS Number
120014-06-4
Product Name Alternative
Cholinesterase (ChE), Donepezil, Donepezilo, E 2020, E2020, E-2020, Aricept, bAChE, AChE, inhibit, Inhibitor, hAChE
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.69% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.27 mM) ; DMSO:97 mg/mL (255.61 mM)
Smiles
O=C1C=2C (=CC (OC) =C (OC) C2) CC1CC3CCN (CC4=CC=CC=C4) CC3
Molecular Formula
C24H29NO3
Molecular Weight
379.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Donepezil

Donepezil is a racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine. It has a role as an EC 3.1.1.8 (cholinesterase) inhibitor, an EC 3.1.1.7 (acetylcholinesterase) inhibitor and a nootropic agent. It contains a (S)-donepezil and a (R)-donepezil. It is a conjugate base of a donepezil (1+).

CAS Number120014-06-4
PubChem CID3152
IUPAC Name2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one
Molecular FormulaC24H29NO3
Molecular Weight379.5
XLogP4.3
Topological Polar Surface Area38.8
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count28
Formal Charge0
Complexity510
SMILES
COC1=C(C=C2C(=C1)CC(C2=O)CC3CCN(CC3)CC4=CC=CC=C4)OC
InChI
InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
InChIKey
ADEBPBSSDYVVLD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Donepezil
CAS: 120014-06-4
CID: 3152
Formula: C24H29NO3
MW: 379.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight379.5
XLogP34.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass379.21474379
Monoisotopic Mass379.21474379
Topological Polar Surface Area38.8 Ų
Heavy Atom Count28
Formal Charge0
Complexity510
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
sc-211231Dehydrodeoxy Donepezil (Donepezil Impurity)
sc-218104Dehydro Donepezil (Donepezil Impurity)
M17876-01Donepezil
447654(-) -Donepezil
574677(+)-Donepezil
T70697-01(+) -Donepezil

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