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Navarixin

CAT: 0013-GTR19167531-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167531-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Navarixin (MK-7123/SCH527123) is a selective CXCR2 antagonist that blocks neutrophil activation and migration. It is a research tool for studying neutrophilic inflammation in models of pulmonary diseases such as COPD and asthma, with demonstrated effects in both in vitro and in vivo experimental systems.
CAS Number
473727-83-2
Product Name Alternative
SCH 527123, SCH527123, SCH-527123, CXC chemokine receptors, CXCR2, CXCR1, CXCR, Inhibitor, inhibit, MK 7123, MK7123, MK-7123, Navarixin
Field of Research
Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.03 mM) ; DMSO:55 mg/mL (138.39 mM)
Smiles
CC[C@@H] (Nc1c (Nc2cccc (C (=O) N (C) C) c2O) c (=O) c1=O) c1ccc (C) o1
Molecular Formula
C21H23N3O5
Molecular Weight
397.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Navarixin Anhydrous

Navarixin has been investigated for the treatment of Asthma.

CAS Number473727-83-2
PubChem CID9865554
IUPAC Name2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamide
Molecular FormulaC21H23N3O5
Molecular Weight397.4
XLogP3.1
Topological Polar Surface Area112
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Heavy Atom Count29
Formal Charge0
Complexity704
SMILES
CC[C@H](C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(C)C
InChI
InChI=1S/C21H23N3O5/c1-5-13(15-10-9-11(2)29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1
InChIKey
RXIUEIPPLAFSDF-CYBMUJFWSA-N
Chemical Structure
2D Structure
2D structure of Navarixin Anhydrous
CAS: 473727-83-2
CID: 9865554
Formula: C21H23N3O5
MW: 397.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight397.4
XLogP33.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count7
Exact Mass397.16377084
Monoisotopic Mass397.16377084
Topological Polar Surface Area112 Ų
Heavy Atom Count29
Formal Charge0
Complexity704
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
206586Navarixin
MBS386848-01SCH-527123 (Navarixin)
C13457-100mgNavarixin (SCH-527123)
A11555-500SCH-527123 (Navarixin) 500mg
A11555-100SCH-527123 (Navarixin) 100mg
A11555-1SCH-527123 (Navarixin) 1mg
A11555-10mM-DSCH-527123 (Navarixin) 10mM * 1mL in DMSO

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