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Capsazepine

CAT: 0013-GTR19167493-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19167493-02Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Capsazepine is a selective TRPV1 receptor antagonist (IC50 = 562 nM) that inhibits capsaicin-induced activation. It is widely used in neuroscience and pain research to study thermal nociception and inflammatory pathways in both in vitro cellular assays and in vivo animal models.
CAS Number
138977-28-3
Product Name Alternative
Transient receptor potential channels, TRPV Channel, TRPVChannel, TRPChannel, TRPA1, TRP Channel, Capsazepine, Apoptosis, Inhibitor, inhibit
Field of Research
Cell Biology, Pharmacology & Drug Discovery
Purity
91.39% (May vary between batches)
Solubility
DMSO:104 mg/mL (275.94 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.27 mM)
Smiles
Oc1cc2CCCN (Cc2cc1O) C (=S) NCCc1ccc (Cl) cc1
Molecular Formula
C19H21ClN2O2S
Molecular Weight
376.9
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Capsazepine

Capsazepine is a benzazepine that is 2,3,4,5-tetrahydro-1H-2-benzazepine which is substituted by hydroxy groups at positions 7 and 8 and on the nitrogen atom by a 2-(p-chlorophenyl)ethylaminothiocarbonyl group. A synthetic analogue of capsaicin, it was the first reported capsaicin receptor antagonist. It has a role as a capsaicin receptor antagonist. It is a member of catechols, a benzazepine, a member of thioureas and a member of monochlorobenzenes.

CAS Number138977-28-3
PubChem CID2733484
IUPAC NameN-[2-(4-chlorophenyl)ethyl]-7,8-dihydroxy-1,3,4,5-tetrahydro-2-benzazepine-2-carbothioamide
Molecular FormulaC19H21ClN2O2S
Molecular Weight376.9
XLogP3.9
Topological Polar Surface Area87.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Heavy Atom Count25
Formal Charge0
Complexity445
SMILES
C1CC2=CC(=C(C=C2CN(C1)C(=S)NCCC3=CC=C(C=C3)Cl)O)O
InChI
InChI=1S/C19H21ClN2O2S/c20-16-5-3-13(4-6-16)7-8-21-19(25)22-9-1-2-14-10-17(23)18(24)11-15(14)12-22/h3-6,10-11,23-24H,1-2,7-9,12H2,(H,21,25)
InChIKey
DRCMAZOSEIMCHM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Capsazepine
CAS: 138977-28-3
CID: 2733484
Formula: C19H21ClN2O2S
MW: 376.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight376.9
XLogP33.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass376.1012268
Monoisotopic Mass376.1012268
Topological Polar Surface Area87.8 Ų
Heavy Atom Count25
Formal Charge0
Complexity445
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
326688Capsazepine

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