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ONO-7475

CAT: 0013-GTR19167114-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19167114-04Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ONO-7475 is a selective small molecule inhibitor targeting the AXL and MER (MERTK) tyrosine kinases. It is a valuable research tool for studying oncogenic signaling in cancer models, demonstrating activity in both in vitro cellular assays and in vivo studies related to leukemia and solid tumors.
CAS Number
1646839-59-9
Product Name Alternative
Acute, advanced, Axl, cancer, EGFR, Inhibitor, Mer, leukemia, inhibit, mutunt, lung, metastatic, NSCLC, ONO 7475, ONO7475, ONO-7475, TAMReceptor, TAM Receptor, solid, tolerant, TKI, tumor, Tyro3, Tropomyosin related kinase receptor, Trk receptor, Trk Receptor, Trkreceptor
Field of Research
Signal Transduction
Purity
98.33% (May vary between batches)
Solubility
DMSO:100 mg/mL (177.76 mM) ;10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (1.78 mM)
Smiles
COc1cc2nccc (Oc3ccc (NC (=O) c4cc5C (=O) CCCc5n (-c5ccccc5) c4=O) nc3) c2cc1OC
Molecular Formula
C32H26N4O6
Molecular Weight
562.57
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Ono-7475

Tamnorzatinib is under investigation in clinical trial NCT03176277 (A Study of ONO-7475 in Patients With Acute Leukemias).

CAS Number1646839-59-9
PubChem CID90645873
IUPAC NameN-[5-(6,7-dimethoxyquinolin-4-yl)oxy-2-pyridinyl]-2,5-dioxo-1-phenyl-7,8-dihydro-6H-quinoline-3-carboxamide
Molecular FormulaC32H26N4O6
Molecular Weight562.6
XLogP3.8
Topological Polar Surface Area120
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count42
Formal Charge0
Complexity1100
SMILES
COC1=CC2=C(C=CN=C2C=C1OC)OC3=CN=C(C=C3)NC(=O)C4=CC5=C(CCCC5=O)N(C4=O)C6=CC=CC=C6
InChI
InChI=1S/C32H26N4O6/c1-40-28-16-21-24(17-29(28)41-2)33-14-13-27(21)42-20-11-12-30(34-18-20)35-31(38)23-15-22-25(9-6-10-26(22)37)36(32(23)39)19-7-4-3-5-8-19/h3-5,7-8,11-18H,6,9-10H2,1-2H3,(H,34,35,38)
InChIKey
WHMMKPWGWNYYFE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Ono-7475
CAS: 1646839-59-9
CID: 90645873
Formula: C32H26N4O6
MW: 562.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight562.6
XLogP33.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass562.18523456
Monoisotopic Mass562.18523456
Topological Polar Surface Area120 Ų
Heavy Atom Count42
Formal Charge0
Complexity1100
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
WQC83959-01ONO-7475
C13795-01Tamnorzatinib (ONO-7475)
A22226-50ONO-7475 50mg
A22226-10ONO-7475 10mg
A22226-1ONO-7475 1mg
A22226-100ONO-7475 100mg
A22226-25ONO-7475 25mg
A22226-5ONO-7475 5mg
A22226-10mM-DONO-7475 10mM * 1mL in DMSO
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