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PD-089828

CAT: 0013-GTR19166963-07Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166963-07Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PD 089828 is a potent small molecule inhibitor targeting key tyrosine kinases. It acts as a competitive inhibitor of FGFR1, PDGFRβ, and EGFR, and a noncompetitive inhibitor of c-Src. This compound is a valuable research tool for studying kinase signaling in cancer and angiogenesis, applicable in both cellular and biochemical assays.
CAS Number
179343-17-0
Product Name Alternative
Src, smooth, Platelet-derived growth factor receptor, PDGFR, PDGFRβ, phosphorylation, vascular, PD089828, PD-089828, PD 089828, muscle, nonselective, inhibit, Inhibitor, HER1, EGFR, Epidermal growth factor receptor, Fibroblast growth factor receptor, FGFR1, FGFR, ErbB-1, cells, competitive, autophosphorylation, ATP, antimigratory, antiproliferative
Field of Research
Cardiovascular Research, Signal Transduction
Purity
96.78% (May vary between batches)
Solubility
DMSO:< 1 mg/mL (insoluble or slightly soluble)
Smiles
CC (C) (C) NC (=O) Nc1nc2nc (N) ncc2cc1-c1c (Cl) cccc1Cl
Molecular Formula
C18H18Cl2N6O
Molecular Weight
405.28
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea
CAS Number179343-17-0
PubChem CID5328112
IUPAC Name1-[2-amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
Molecular FormulaC18H18Cl2N6O
Molecular Weight405.3
XLogP3.7
Topological Polar Surface Area106
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity520
SMILES
CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl
InChI
InChI=1S/C18H18Cl2N6O/c1-18(2,3)26-17(27)25-15-10(13-11(19)5-4-6-12(13)20)7-9-8-22-16(21)24-14(9)23-15/h4-8H,1-3H3,(H4,21,22,23,24,25,26,27)
InChIKey
RRWSNCZYJCOEFX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl)-3-(tert-butyl)urea
CAS: 179343-17-0
CID: 5328112
Formula: C18H18Cl2N6O
MW: 405.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight405.3
XLogP33.7
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass404.0919146
Monoisotopic Mass404.0919146
Topological Polar Surface Area106 Ų
Heavy Atom Count27
Formal Charge0
Complexity520
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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