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NSC45586

CAT: 0013-GTR19166953-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166953-04Size:25 mg
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Description
NSC45586 is a selective small molecule inhibitor of the protein phosphatases PHLPP1 and PHLPP2. It is a valuable research tool for studying the Akt and PKC signaling pathways in cancer biology, utilized in both cellular and in vivo experimental models.
CAS Number
6300-44-3
Product Name Alternative
PP2C, PHLPP, PHLPP1, PHLPP2, Inhibitor, NSC 45586, inhibit, NSC-45586, NSC45586, pleckstrin homology domain and leucine-rich repeat protein phosphatase, AKT
Field of Research
Protein Biochemistry, Signal Transduction
Purity
95.09% (May vary between batches)
Solubility
Ethanol:Insoluble; H2O:Insoluble; DMSO:82 mg/mL (198.36 mM)
Smiles
CC1=CC (=C (C=C1N) N) N=NC2=CC=C (C=C2) N=NC3=CC (=C (C=C3) O) C (=O) O.[Na+]
Molecular Formula
C20H18N6NaO3+
Molecular Weight
413.4
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

NSC45586 sodium
CAS Number6300-44-3
PubChem CID137530162
IUPAC Namesodium 5-[[4-[(2,4-diamino-5-methylphenyl)diazenyl]phenyl]diazenyl]-2-hydroxybenzoate
Molecular FormulaC20H17N6NaO3
Molecular Weight412.4
Topological Polar Surface Area162
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity613
SMILES
CC1=CC(=C(C=C1N)N)N=NC2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)[O-].[Na+]
InChI
InChI=1S/C20H18N6O3.Na/c1-11-8-18(17(22)10-16(11)21)26-24-13-4-2-12(3-5-13)23-25-14-6-7-19(27)15(9-14)20(28)29;/h2-10,27H,21-22H2,1H3,(H,28,29);/q;+1/p-1
InChIKey
XPYXCDXPWJROPD-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of NSC45586 sodium
CAS: 6300-44-3
CID: 137530162
Formula: C20H17N6NaO3
MW: 412.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight412.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass412.12598271
Monoisotopic Mass412.12598271
Topological Polar Surface Area162 Ų
Heavy Atom Count30
Formal Charge0
Complexity613
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5765117NSC45586
HY-19820A-01NSC45586 (sodium)

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