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Bisdemethoxycurcumin

CAT: 0013-GTR19166576-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166576-03Size:10 mg
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Description
Bisdemethoxycurcumin (Curcumin III) is a stable curcumin derivative that enhances macrophage phagocytosis, particularly in amyloid-β clearance research. It exhibits anticancer properties by suppressing proliferation via p300/Wnt/β-catenin pathway inhibition and modulates inflammation by reducing LPS-induced iNOS expression in vitro.
CAS Number
24939-16-0
Product Name Alternative
Antioxidant, antiinflammatory, bcatenin, Bisdemethoxycucurmin, Bisdemethoxycurcumin, betacatenin, beta-catenin, Curcumin III, curcuminoid, Didemethoxycurcumin, inhibit, Inhibitor, Epigenetic Reader Domain, EpigeneticReaderDomain, βcatenin, Wnt, Wnt/β-catenin, Wnt/betacatenin, Wnt/b-catenin, p300
Field of Research
Cell Biology, Epigenetics & Chromatin, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction, Stem Cell & Developmental Biology
Purity
99.34% (May vary between batches)
Solubility
Ethanol:5 mg/mL (16.22 mM) ; DMSO:67 mg/mL (217.3 mM)
Smiles
Oc1ccc (\C=C\C (=O) CC (=O) \C=C\c2ccc (O) cc2) cc1
Molecular Formula
C19H16O4
Molecular Weight
308.33
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Bisdemethoxycurcumin

Bisdemethoxycurcumin is a beta-diketone that is methane in which two of the hydrogens are substituted by 4-hydroxycinnamoyl groups. It has a role as a metabolite and an EC 3.2.1.1 (alpha-amylase) inhibitor. It is a polyphenol, an enone, a beta-diketone and a diarylheptanoid. It is functionally related to a 4-coumaric acid.

CAS Number24939-16-0
PubChem CID5315472
IUPAC Name(1E,6E)-1,7-bis(4-hydroxyphenyl)hepta-1,6-diene-3,5-dione
Molecular FormulaC19H16O4
Molecular Weight308.3
XLogP3.3
Topological Polar Surface Area74.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count23
Formal Charge0
Complexity408
SMILES
C1=CC(=CC=C1/C=C/C(=O)CC(=O)/C=C/C2=CC=C(C=C2)O)O
InChI
InChI=1S/C19H16O4/c20-16-7-1-14(2-8-16)5-11-18(22)13-19(23)12-6-15-3-9-17(21)10-4-15/h1-12,20-21H,13H2/b11-5+,12-6+
InChIKey
PREBVFJICNPEKM-YDWXAUTNSA-N
Chemical Structure
2D Structure
2D structure of Bisdemethoxycurcumin
CAS: 24939-16-0
CID: 5315472
Formula: C19H16O4
MW: 308.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight308.3
XLogP33.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass308.10485899
Monoisotopic Mass308.10485899
Topological Polar Surface Area74.6 Ų
Heavy Atom Count23
Formal Charge0
Complexity408
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count2
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
ZAA93916-01Bisdemethoxycurcumin
A14544-5Bisdemethoxycurcumin 5mg
S3938-01Bisdemethoxycurcumin (BDMC)

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