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Diphyllin

CAT: 0013-GTR19166658-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166658-01Size:1 mg
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Description
Diphyllin is a novel V-ATPase inhibitor with research applications in gastric cancer. It suppresses tumor cell growth by inhibiting the Wnt/β-catenin pathway via blocking LRP6 phosphorylation, as demonstrated in in vitro studies.
CAS Number
22055-22-7
Product Name Alternative
Protonpump, Proton Pump, Proton pump, Wnt/β-catenin, Vesicular stomatitis virus (VSV), Vacuolar type H+-ATPase, VSV, virus, cytotoxicity, Diphyllin, c-Myc, antiviral, arylnaphthalene, ATPase, lignan, inhibit, influenza, InfluenzaVirus, Influenza Virus, Inhibitor, HIV, HIVProtease, HIV Protease, HIV-1, Human immunodeficiency virus
Field of Research
Infectious Disease & Virology, Pharmacology & Drug Discovery, Protein Biochemistry
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.63 mM) ; DMSO:3.81 mg/mL (10.02 mM)
Smiles
COc1cc2c (O) c3COC (=O) c3c (-c3ccc4OCOc4c3) c2cc1OC
Molecular Formula
C21H16O7
Molecular Weight
380.35
Storage Conditions
Keep away from direct sunlight, store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

9-(1,3-Benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphtho(2,3-c)furan-1(3H)-one

Diphyllin is a lignan.

CAS Number22055-22-7
PubChem CID100492
IUPAC Name9-(1,3-benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxy-3H-benzo[f][2]benzofuran-1-one
Molecular FormulaC21H16O7
Molecular Weight380.3
XLogP3.6
Topological Polar Surface Area83.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count28
Formal Charge0
Complexity597
SMILES
COC1=C(C=C2C(=C1)C(=C3C(=C2O)COC3=O)C4=CC5=C(C=C4)OCO5)OC
InChI
InChI=1S/C21H16O7/c1-24-15-6-11-12(7-16(15)25-2)20(22)13-8-26-21(23)19(13)18(11)10-3-4-14-17(5-10)28-9-27-14/h3-7,22H,8-9H2,1-2H3
InChIKey
VMEJANRODATDOF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 9-(1,3-Benzodioxol-5-yl)-4-hydroxy-6,7-dimethoxynaphtho(2,3-c)furan-1(3H)-one
CAS: 22055-22-7
CID: 100492
Formula: C21H16O7
MW: 380.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight380.3
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass380.08960285
Monoisotopic Mass380.08960285
Topological Polar Surface Area83.5 Ų
Heavy Atom Count28
Formal Charge0
Complexity597
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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