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SR-717

CAT: 0013-GTR19165975-03Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165975-03Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR-717 is a non-nucleoside STING agonist analog of cGAMP that stabilizes the protein in a closed, active conformation. It has demonstrated antitumor efficacy in preclinical models by enhancing immune cell activation and antigen cross-presentation in both cellular and animal studies.
CAS Number
2375421-09-1
Product Name Alternative
SR 717, SR717, SR-717, STING, Stimulator of Interferon Genes, TMEM173, THP1, inhibit, ISG-THP1, MPYS, PD-L1, MITA, mimetic, immunity, Inhibitor, ERIS, cGAMP, antitumor
Field of Research
Immunology & Inflammation
Purity
98.24% (May vary between batches)
Solubility
DMSO:20 mg/mL (56.95 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.5 mg/mL (7.12 mM)
Smiles
[Li+].[O-]C (=O) c1cc (F) c (F) cc1NC (=O) c1ccc (nn1) -n1ccnc1
Molecular Formula
C15H8F2LiN5O3
Molecular Weight
351.19
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

SR-717 lithium
CAS Number2375421-09-1
PubChem CID139434658
IUPAC Namelithium 4,5-difluoro-2-[(6-imidazol-1-ylpyridazine-3-carbonyl)amino]benzoate
Molecular FormulaC15H8F2LiN5O3
Molecular Weight351.2
Topological Polar Surface Area113
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity518
SMILES
[Li+].C1=CC(=NN=C1C(=O)NC2=CC(=C(C=C2C(=O)[O-])F)F)N3C=CN=C3
InChI
InChI=1S/C15H9F2N5O3.Li/c16-9-5-8(15(24)25)12(6-10(9)17)19-14(23)11-1-2-13(21-20-11)22-4-3-18-7-22;/h1-7H,(H,19,23)(H,24,25);/q;+1/p-1
InChIKey
ODSAJRWPLSVEHJ-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of SR-717 lithium
CAS: 2375421-09-1
CID: 139434658
Formula: C15H8F2LiN5O3
MW: 351.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight351.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass351.07552389
Monoisotopic Mass351.07552389
Topological Polar Surface Area113 Ų
Heavy Atom Count26
Formal Charge0
Complexity518
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
B8463-50SR-717
B3216-25SR-717 Lithium
A22048-100SR-717 100mg
A22048-10SR-717 10mg
A22048-2SR-717 2mg
S0853-5mgSR-717 lithium
A22048-5SR-717 5mg
A22048-50SR-717 50mg
A22048-25SR-717 25mg

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