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HBT1

CAT: 0013-GTR19165872-01Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19165872-01Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HBT1 is a glutamate-dependent AMPA receptor potentiator that enhances receptor activity and stimulates BDNF production with minimal intrinsic agonism in primary neurons. This molecule is used in vitro and in vivo to study synaptic plasticity, neuroprotection, and cognitive function in models of neurological disorders.
CAS Number
489408-02-8
Product Name Alternative
BDNF, AMPA-R, AMPA, inhibit, Ionotropic glutamate receptors, Inhibitor, HBT 1, HBT1, HBT-1, iGluR, LBD, glutamate, primary neurons, S518
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
99.48% (May vary between batches)
Solubility
DMSO:3.87 mg/mL (10.02 mM)
Smiles
Cc1cc (nn1CC (=O) Nc1sc2CCCCc2c1C (N) =O) C (F) (F) F
Molecular Formula
C16H17F3N4O2S
Molecular Weight
386.39
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

2-(((5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS Number489408-02-8
PubChem CID1222102
IUPAC Name2-[[2-[5-methyl-3-(trifluoromethyl)pyrazol-1-yl]acetyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
Molecular FormulaC16H17F3N4O2S
Molecular Weight386.4
XLogP3.2
Topological Polar Surface Area118
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity562
SMILES
CC1=CC(=NN1CC(=O)NC2=C(C3=C(S2)CCCC3)C(=O)N)C(F)(F)F
InChI
InChI=1S/C16H17F3N4O2S/c1-8-6-11(16(17,18)19)22-23(8)7-12(24)21-15-13(14(20)25)9-4-2-3-5-10(9)26-15/h6H,2-5,7H2,1H3,(H2,20,25)(H,21,24)
InChIKey
PHLXSNIEQIKENK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(((5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl)acetyl)amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide
CAS: 489408-02-8
CID: 1222102
Formula: C16H17F3N4O2S
MW: 386.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight386.4
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count4
Exact Mass386.10243146
Monoisotopic Mass386.10243146
Topological Polar Surface Area118 Ų
Heavy Atom Count26
Formal Charge0
Complexity562
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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