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AMG131

CAT: 0013-GTR19165871-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165871-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AMG131 (CHS 131) is a selective PPARγ modulator for type 2 diabetes research. As a non-TZD compound, it is utilized in studies investigating insulin sensitization and glucose metabolism, with applications in both in vitro cellular assays and in vivo diabetic animal models.
CAS Number
315224-26-1
Product Name Alternative
Diabetes, CHS 131, CHS-131, CHS131, activated, AMG131, AMG-131, AMG 131, inhibit, INT 131, INT131, INT-131, Inhibitor, mellitus, receptor, PPARγ, PPAR, Peroxisome proliferator-activated receptors, peroxisome, T2DM, SPPARM, proliferator
Field of Research
Metabolism Research, Molecular Biology
Purity
98.01% (May vary between batches)
Solubility
DMSO:27.5 mg/mL (53.48 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.89 mM)
Smiles
Clc1ccc (c (Cl) c1) S (=O) (=O) Nc1cc (Cl) c (Oc2cnc3ccccc3c2) c (Cl) c1
Molecular Formula
C21H12Cl4N2O3S
Molecular Weight
514.21
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Amg-131

AMG-131 (T131), an orally-administered therapy, is expected to lower blood glucose in type II diabetic patients by improving the body’s ability to respond to insulin. T131 is a selective modulator of PPARg (peroxisome proliferator activated receptor gamma), a receptor involved in regulating the body’s ability to respond to insulin. T131 is not structurally related to the thiazolidinedione class of PPARg agonists, which includes Actos and Avandia.

CAS Number315224-26-1
PubChem CID10229498
IUPAC Name2,4-dichloro-N-(3,5-dichloro-4-quinolin-3-yloxyphenyl)benzenesulfonamide
Molecular FormulaC21H12Cl4N2O3S
Molecular Weight514.2
XLogP6.8
Topological Polar Surface Area76.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity697
SMILES
C1=CC=C2C(=C1)C=C(C=N2)OC3=C(C=C(C=C3Cl)NS(=O)(=O)C4=C(C=C(C=C4)Cl)Cl)Cl
InChI
InChI=1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H
InChIKey
NMRWDFUZLLQSBN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Amg-131
CAS: 315224-26-1
CID: 10229498
Formula: C21H12Cl4N2O3S
MW: 514.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight514.2
XLogP36.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass513.929324
Monoisotopic Mass511.932274
Topological Polar Surface Area76.7 Ų
Heavy Atom Count31
Formal Charge0
Complexity697
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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