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IMT1B

CAT: 0013-GTR19165823-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165823-04Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IMT1B (LDC203974) is an orally bioavailable, specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) that suppresses mtDNA transcription, conferring anti-tumor activity. It is used in cancer research to study mitochondrial metabolism and has demonstrated efficacy in both in vitro and in vivo experimental models.
CAS Number
2304621-06-3
Product Name Alternative
RNASynthesis, RNA Synthesis, RNA, polymerase, oxidative, OXPHOS, POLRMT, phosphorylation, mitochondrial, inhibit, mtDNA, IMT1B, IMT-1B, Inhibitor, LDC 203974, LDC203974, LDC-203974, human, 3-Piperidinecarboxylic acid, 1-[ (2R) -2-[[4- (2-chloro-4-fluorophenyl) -2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S) -, anti-tumour, DNASynthesis, DNA Synthesis, DNA
Field of Research
Cell Biology, Molecular Biology
Purity
95.22% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (10.55 mM) ; DMSO:16.9 mg/mL (35.66 mM)
Smiles
C[C@@H] (Oc1ccc2c (cc (=O) oc2c1) -c1ccc (F) cc1Cl) C (=O) N1CCC[C@@H] (C1) C (O) =O
Molecular Formula
C24H21ClFNO6
Molecular Weight
473.88
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(S)-1-((R)-2-((4-(2-Chloro-4-fluorophenyl)-2-oxo-2H-chromen-7-yl)oxy)propanoyl)piperidine-3-carboxylic acid
CAS Number2304621-06-3
PubChem CID138490769
IUPAC Name(3S)-1-[(2R)-2-[4-(2-chloro-4-fluorophenyl)-2-oxochromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid
Molecular FormulaC24H21ClFNO6
Molecular Weight473.9
XLogP3.7
Topological Polar Surface Area93.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count33
Formal Charge0
Complexity806
SMILES
C[C@H](C(=O)N1CCC[C@@H](C1)C(=O)O)OC2=CC3=C(C=C2)C(=CC(=O)O3)C4=C(C=C(C=C4)F)Cl
InChI
InChI=1S/C24H21ClFNO6/c1-13(23(29)27-8-2-3-14(12-27)24(30)31)32-16-5-7-18-19(11-22(28)33-21(18)10-16)17-6-4-15(26)9-20(17)25/h4-7,9-11,13-14H,2-3,8,12H2,1H3,(H,30,31)/t13-,14+/m1/s1
InChIKey
PFEKWBKJUBCXDT-KGLIPLIRSA-N
Chemical Structure
2D Structure
2D structure of (S)-1-((R)-2-((4-(2-Chloro-4-fluorophenyl)-2-oxo-2H-chromen-7-yl)oxy)propanoyl)piperidine-3-carboxylic acid
CAS: 2304621-06-3
CID: 138490769
Formula: C24H21ClFNO6
MW: 473.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight473.9
XLogP33.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass473.1041432
Monoisotopic Mass473.1041432
Topological Polar Surface Area93.1 Ų
Heavy Atom Count33
Formal Charge0
Complexity806
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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