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Tolebrutinib

CAT: 0013-GTR19165781-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165781-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tolebrutinib is a potent, selective, and brain-penetrant BTK inhibitor with IC50 values of 0.4 nM and 0.7 nM in Ramos B cells and HMC microglia cells, respectively. It is an orally active compound used in research for multiple sclerosis, demonstrating efficacy in models of central nervous system immunity.
CAS Number
1971920-73-6
Product Name Alternative
Bruton tyrosine kinase, Bruton, BTK, Btk, inhibit, multiple, kinase, Inhibitor, PRN2246, PRN-2246, PRN 2246, SAR442168, SAR-442168, SAR 442168, sclerosis, Tolebrutinib, tyrosine
Field of Research
Cardiovascular Research, Signal Transduction
Purity
98.40% (May vary between batches)
Solubility
DMSO:100 mg/mL (219.53 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.78 mM)
Smiles
Nc1nccc2n ([C@@H]3CCCN (C3) C (=O) C=C) c (=O) n (-c3ccc (Oc4ccccc4) cc3) c12
Molecular Formula
C26H25N5O3
Molecular Weight
455.51
Storage Conditions
-20°C
Notes
For research use only.

Alternative Products

CatalogName
MBS3613549-01Tolebrutinib

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