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G140

CAT: 0013-GTR19165707-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165707-06Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
G140 is a potent and selective small molecule inhibitor of the cGAS enzyme. It is a valuable research tool for investigating the cGAS-STING signaling pathway in both cellular and animal models of autoimmunity, inflammation, and cancer.
CAS Number
2369751-07-3
Product Name Alternative
Anti-inflammatory, cyclic, Cyclic GMP-AMP Synthase, cGAS, inhibit, Inhibitor, GMP-AMP, G140, G-140, G 140, synthase
Field of Research
Immunology & Inflammation
Purity
98.16% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.18 mM) ; DMSO:247 mg/mL (651.3 mM)
Smiles
ClC1=C2C (C3=C (N2) CCN (C (CO) =O) C3) =C (C=C1Cl) C=4C=CN (C) N4
Molecular Formula
C17H16Cl2N4O2
Molecular Weight
379.24
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)-2-hydroxyethanone
CAS Number2369751-07-3
PubChem CID139388865
IUPAC Name1-[6,7-dichloro-9-(1-methylpyrazol-3-yl)-1,3,4,5-tetrahydropyrido[4,3-b]indol-2-yl]-2-hydroxyethanone
Molecular FormulaC17H16Cl2N4O2
Molecular Weight379.2
XLogP2
Topological Polar Surface Area74.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count25
Formal Charge0
Complexity525
SMILES
CN1C=CC(=N1)C2=CC(=C(C3=C2C4=C(N3)CCN(C4)C(=O)CO)Cl)Cl
InChI
InChI=1S/C17H16Cl2N4O2/c1-22-4-2-13(21-22)9-6-11(18)16(19)17-15(9)10-7-23(14(25)8-24)5-3-12(10)20-17/h2,4,6,20,24H,3,5,7-8H2,1H3
InChIKey
NVPFAXHXXODQRO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(6,7-Dichloro-9-(1-methyl-1H-pyrazol-3-yl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-yl)-2-hydroxyethanone
CAS: 2369751-07-3
CID: 139388865
Formula: C17H16Cl2N4O2
MW: 379.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight379.2
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass378.0650312
Monoisotopic Mass378.0650312
Topological Polar Surface Area74.2 Ų
Heavy Atom Count25
Formal Charge0
Complexity525
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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