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Norathyriol

CAT: 0013-GTR19165164-08Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165164-08Size:200 mg
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Description
Norathyriol is a cell-permeable, orally bioavailable small molecule that potently inhibits the protein tyrosine phosphatase PTP1B. It is utilized in research areas such as diabetes and obesity, demonstrating activity in both cellular assays and animal models of metabolic disease.
CAS Number
3542-72-1
Product Name Alternative
PPAR, Peroxisome proliferator-activated receptors, RNASynthesis, RNA Synthesis, α-glucosidase, Glucosidase, Inhibitor, Mangifera, Mangiferitin, Norathyriol, inhibit, Natural, metabolite, DNASynthesis, DNA Synthesis, AMPK, anticancer, anti-bacterial, Antioxidant, antimicrobial, anti-inflammatory, AP-1, Akt
Field of Research
Cell Biology, Epigenetics & Chromatin, Metabolism Research, Molecular Biology, Signal Transduction
Purity
98.90% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.69 mM) ; DMSO:65 mg/mL (249.81 mM)
Smiles
Oc1cc (O) c2c (c1) oc1cc (O) c (O) cc1c2=O
Molecular Formula
C13H8O6
Molecular Weight
260.2
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

Norathyriol

Norathyriol is a member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7. Isolated from Garcinia mangostana and Maclura pomifera, it exhibits inhibitory activity against protein kinase C. It has a role as an antineoplastic agent, an EC 2.7.11.13 (protein kinase C) inhibitor and a plant metabolite. It is a polyphenol and a member of xanthones.

CAS Number3542-72-1
PubChem CID5281656
IUPAC Name1,3,6,7-tetrahydroxyxanthen-9-one
Molecular FormulaC13H8O6
Molecular Weight260.20
XLogP2.1
Topological Polar Surface Area107
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Heavy Atom Count19
Formal Charge0
Complexity372
SMILES
C1=C(C=C2C(=C1O)C(=O)C3=CC(=C(C=C3O2)O)O)O
InChI
InChI=1S/C13H8O6/c14-5-1-9(17)12-11(2-5)19-10-4-8(16)7(15)3-6(10)13(12)18/h1-4,14-17H
InChIKey
ZHTQCPCDXKMMLU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Norathyriol
CAS: 3542-72-1
CID: 5281656
Formula: C13H8O6
MW: 260.20
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight260.20
XLogP32.1
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count0
Exact Mass260.03208797
Monoisotopic Mass260.03208797
Topological Polar Surface Area107 Ų
Heavy Atom Count19
Formal Charge0
Complexity372
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19193314-01Norathiol

Alternative Products

CatalogName
DAA54272-01Norathyriol

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