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Mogrol

CAT: 0013-GTR19165053-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19165053-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mogrol, the bioactive aglycone of mogrosides, acts as a signaling modulator by suppressing ERK1/2 and STAT3 pathways while activating AMPK, which concurrently reduces CREB activity. This mechanism supports its research utility in metabolic and inflammation studies, applicable in both cellular and animal models.
CAS Number
88930-15-8
Product Name Alternative
Extracellular signal regulated kinases, ERK2, ERK, ERK1, Inhibitor, Mogrol, inhibit, STAT, STAT3
Field of Research
Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.21% (May vary between batches)
Solubility
DMSO:110 mg/mL (230.74 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.39 mM)
Smiles
[H][C@@]12CC[C@H] (O) C (C) (C) C1=CC[C@@]1 ([H]) [C@]3 (C) CC[C@H] ([C@H] (C) CC[C@@H] (O) C (C) (C) O) [C@@]3 (C) C[C@@H] (O) [C@@]21C
Molecular Formula
C30H52O4
Molecular Weight
476.73
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

Mogrol

Mogrol is a tetracyclic triterpenoid that is cucurbitadienol in which the side-chain double bond (position 24-25) has undergone formal oxidation to introduce hydroxy groups at positions 24 and 25 (the 24R stereoisomer). It is a biometabolite of mogrosides found in Siraitia grosvenorii. It has a role as an antineoplastic agent. It is a tetracyclic triterpenoid and a hydroxy seco-steroid. It is functionally related to a cucurbitadienol.

CAS Number88930-15-8
PubChem CID14525327
IUPAC Name(3S,8S,9R,10R,11R,13R,14S,17R)-17-[(2R,5R)-5,6-dihydroxy-6-methylheptan-2-yl]-4,4,9,13,14-pentamethyl-2,3,7,8,10,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthrene-3,11-diol
Molecular FormulaC30H52O4
Molecular Weight476.7
XLogP5.4
Topological Polar Surface Area80.9
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count34
Formal Charge0
Complexity817
SMILES
C[C@H](CC[C@H](C(C)(C)O)O)[C@H]1CC[C@@]2([C@@]1(C[C@H]([C@@]3([C@H]2CC=C4[C@H]3CC[C@@H](C4(C)C)O)C)O)C)C
InChI
InChI=1S/C30H52O4/c1-18(9-13-24(32)27(4,5)34)19-15-16-28(6)22-12-10-20-21(11-14-23(31)26(20,2)3)30(22,8)25(33)17-29(19,28)7/h10,18-19,21-25,31-34H,9,11-17H2,1-8H3/t18-,19-,21-,22+,23+,24-,25-,28+,29-,30+/m1/s1
InChIKey
JLYBBRAAICDTIS-AYEHCKLZSA-N
Chemical Structure
2D Structure
2D structure of Mogrol
CAS: 88930-15-8
CID: 14525327
Formula: C30H52O4
MW: 476.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight476.7
XLogP35.4
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass476.38656014
Monoisotopic Mass476.38656014
Topological Polar Surface Area80.9 Ų
Heavy Atom Count34
Formal Charge0
Complexity817
Isotope Atom Count0
Defined Atom Stereocenter Count10
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M24913-01Mogrol
A24196-100Mogrol 100mg
A24196-5Mogrol 5mg
A24196-10Mogrol 10mg
HY-N2312R-01Mogrol (Standard)
A24196-50Mogrol 50mg
TRC-O366670-10MG11-Oxo-Mogrol
M382703-O-β-D-Glucopyranosyl- (1-3) -β-D-glucopyranosyl- mogrol 24-O-β-D-glucopyranosyl- (1-2) -[β-D- glucopyranosyl - (1-6) ]-β-D-glucopyranosyl

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