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PYRIB-SO 2

CAT: 0804-HY-163523Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163523Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PYRIB-SO 2 is a potent antimitotic agent. PYRIB-SO 2 shows antiproliferative activity and induces cell cycle arrest at G2/M phase. PYRIB-SO 2 reduces and disruptes microtubule structures. PYRIB-SO 2 binds to the colchicine-binding site (C-BS) of α, β-tubulin[1].
UNSPSC
12352005
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pyrib-so-2.html
Solubility
10 mM in DMSO
Smiles
ClC1=CC(OS(=O)(C2=CC=C(C=C2)N3CCNC3=O)=O)=CN=C1
Molecular Formula
C14H12ClN3O4S
Molecular Weight
353.78
References & Citations
[1]Ouellette V, et al. Modification of the phenyl ring B of phenyl 4- (2-oxoimidazolidin-1-yl) benzenesulfonates by pyridinyl moiety leads to novel antimitotics targeting the colchicine-binding site. Bioorg Med Chem Lett. 2024 Jun 1;105:129745.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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