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DCBP-1

CAT: 0013-GTR19164858-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164858-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DCBP-1 is a small molecule that selectively degrades the p300/CBP proteins by recruiting the CRBN E3 ubiquitin ligase. This targeted degradation has demonstrated potent anti-proliferative effects in multiple myeloma cell lines in vitro, supporting its use as a chemical probe in oncology and epigenetics research.
CAS Number
2484739-25-3
Product Name Alternative
Cereblon, cell, CBP/p300, CBP, CRBN, degrader, Epigenetic Reader Domain, EpigeneticReaderDomain, dCBP 1, dCBP1, dCBP-1, heterobifunctional, Inhibitor, inhibit, myeloma, MYC, multiple, p300, PROTACs
Field of Research
Epigenetics & Chromatin, Pharmacology & Drug Discovery
Purity
98.21% (May vary between batches)
Solubility
DMSO:50 mg/mL (48.63 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (1.95 mM)
Smiles
C (NC) (=O) N1CC=2C (=NN (C2CC1) C3CCN (C (CCOCCOCCOCCOCCNC=4C=C5C (=CC4) C (=O) N (C5=O) C6C (=O) NC (=O) CC6) =O) CC3) N7C=8C (=CC (=C (C (F) F) C8) C9=CN (C) N=C9) CCC7
Molecular Formula
C51H63F2N11O10
Molecular Weight
1028.11
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-yl]-1-[1-(1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]amino}-3,6,9,12-tetraoxapentadecanoyl)piperidin-4-yl]-N-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxamide
CAS Number2484739-25-3
PubChem CID154690309
IUPAC Name3-[7-(difluoromethyl)-6-(1-methylpyrazol-4-yl)-3,4-dihydro-2H-quinolin-1-yl]-1-[1-[3-[2-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoyl]piperidin-4-yl]-N-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-carboxamide
Molecular FormulaC51H63F2N11O10
Molecular Weight1028.1
XLogP1.6
Topological Polar Surface Area224
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count16
Rotatable Bond Count21
Heavy Atom Count74
Formal Charge0
Complexity1960
SMILES
CNC(=O)N1CCC2=C(C1)C(=NN2C3CCN(CC3)C(=O)CCOCCOCCOCCOCCNC4=CC5=C(C=C4)C(=O)N(C5=O)C6CCC(=O)NC6=O)N7CCCC8=CC(=C(C=C87)C(F)F)C9=CN(N=C9)C
InChI
InChI=1S/C51H63F2N11O10/c1-54-51(70)61-17-11-41-40(31-61)47(62-14-3-4-32-26-37(33-29-56-59(2)30-33)38(46(52)53)28-43(32)62)58-64(41)35-9-15-60(16-10-35)45(66)12-18-71-20-22-73-24-25-74-23-21-72-19-13-55-34-5-6-36-39(27-34)50(69)63(49(36)68)42-7-8-44(65)57-48(42)67/h5-6,26-30,35,42,46,55H,3-4,7-25,31H2,1-2H3,(H,54,70)(H,57,65,67)
InChIKey
ILVRLRGBSSFKIE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-[7-(difluoromethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydroquinolin-1-yl]-1-[1-(1-{[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-yl]amino}-3,6,9,12-tetraoxapentadecanoyl)piperidin-4-yl]-N-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-5-carboxamide
CAS: 2484739-25-3
CID: 154690309
Formula: C51H63F2N11O10
MW: 1028.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight1028.1
XLogP31.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count16
Rotatable Bond Count21
Exact Mass1027.47274357
Monoisotopic Mass1027.47274357
Topological Polar Surface Area224 Ų
Heavy Atom Count74
Formal Charge0
Complexity1960
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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