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MF-766

CAT: 0013-GTR19164683-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164683-07Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MF-766 is a highly potent and selective oral EP4 receptor antagonist with sub-nanomolar affinity (Ki = 0.23 nM) . It demonstrates full antagonistic activity in functional assays and is a valuable research tool for studying cancer and inflammatory diseases in both in vitro and in vivo models.
CAS Number
1050656-06-8
Product Name Alternative
Inhibit, inflammation disease, MF 766, MF766, MF-766, EP4, Inhibitor, cancer, arthritis, anti-tumor, AIA, Prostaglandin Receptor, ProstaglandinReceptor
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Purity
98.00% (May vary between batches)
Solubility
DMSO:60 mg/mL (125.4 mM) ;10% DMSO+90% Corn Oil:2.5 mg/mL (5.23 mM)
Smiles
OC (=O) c1ccc (cc1) C1 (CC1) NC (=O) c1cccc2ccn (Cc3ccc (cc3) C (F) (F) F) c12
Molecular Formula
C27H21F3N2O3
Molecular Weight
478.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxamido)cyclopropyl)benzoic acid
CAS Number1050656-06-8
PubChem CID25003075
IUPAC Name4-[1-[[1-[[4-(trifluoromethyl)phenyl]methyl]indole-7-carbonyl]amino]cyclopropyl]benzoic acid
Molecular FormulaC27H21F3N2O3
Molecular Weight478.5
XLogP5.1
Topological Polar Surface Area71.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count35
Formal Charge0
Complexity783
SMILES
C1CC1(C2=CC=C(C=C2)C(=O)O)NC(=O)C3=CC=CC4=C3N(C=C4)CC5=CC=C(C=C5)C(F)(F)F
InChI
InChI=1S/C27H21F3N2O3/c28-27(29,30)21-8-4-17(5-9-21)16-32-15-12-18-2-1-3-22(23(18)32)24(33)31-26(13-14-26)20-10-6-19(7-11-20)25(34)35/h1-12,15H,13-14,16H2,(H,31,33)(H,34,35)
InChIKey
BWXAZFCPGFKANL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-carboxamido)cyclopropyl)benzoic acid
CAS: 1050656-06-8
CID: 25003075
Formula: C27H21F3N2O3
MW: 478.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight478.5
XLogP35.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass478.15042702
Monoisotopic Mass478.15042702
Topological Polar Surface Area71.3 Ų
Heavy Atom Count35
Formal Charge0
Complexity783
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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