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SR-3677

CAT: 0013-GTR19164544-02Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164544-02Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR-3677 is a potent and selective ROCK2 inhibitor with an IC50 of 3 nM. This compound is a valuable research tool for investigating Rho-kinase signaling in cellular assays and has been utilized in preclinical studies exploring fibrosis, hypertension, and neurological disorders.
CAS Number
1072959-67-1
Product Name Alternative
Autophagy, Inhibitor, inhibit, ROK, ROCK, ROCK1, ROCK2, Rho-associated kinase, Rho-associated protein kinase, Rho-kinase, SR 3677, SR3677, SR-3677
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.46% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.9 mM) ; DMSO:40 mg/mL (97.93 mM)
Smiles
CN (C) CCOc1cc (ccc1NC (=O) C1COc2ccccc2O1) -c1cn[nH]c1
Molecular Formula
C22H24N4O4
Molecular Weight
408.45
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS Number1072959-67-1
PubChem CID25093235
IUPAC NameN-[2-[2-(dimethylamino)ethoxy]-4-(1H-pyrazol-4-yl)phenyl]-2,3-dihydro-1,4-benzodioxine-3-carboxamide
Molecular FormulaC22H24N4O4
Molecular Weight408.4
XLogP2.5
Topological Polar Surface Area88.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count30
Formal Charge0
Complexity563
SMILES
CN(C)CCOC1=C(C=CC(=C1)C2=CNN=C2)NC(=O)C3COC4=CC=CC=C4O3
InChI
InChI=1S/C22H24N4O4/c1-26(2)9-10-28-20-11-15(16-12-23-24-13-16)7-8-17(20)25-22(27)21-14-29-18-5-3-4-6-19(18)30-21/h3-8,11-13,21H,9-10,14H2,1-2H3,(H,23,24)(H,25,27)
InChIKey
OQWZIAVXCYIZNN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(2-(2-(dimethylamino)ethoxy)-4-(1H-pyrazol-4-yl)phenyl)-2,3-dihydrobenzo[b][1,4]dioxine-2-carboxamide
CAS: 1072959-67-1
CID: 25093235
Formula: C22H24N4O4
MW: 408.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight408.4
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass408.17975526
Monoisotopic Mass408.17975526
Topological Polar Surface Area88.7 Ų
Heavy Atom Count30
Formal Charge0
Complexity563
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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