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LY450108

CAT: 0013-GTR19164469-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164469-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY450108 is a positive allosteric modulator of the AMPA receptor. This compound serves as a research tool for investigating synaptic plasticity and has been utilized in both in vitro and in vivo models relevant to Parkinson's disease research.
CAS Number
376594-67-1
Product Name Alternative
Inhibit, Ionotropic glutamate receptors, Inhibitor, Parkinson's, LY450108, LY-450108, LY 450108, iGluR, AMPAR, AMPA, depression
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Purity
98.80% (May vary between batches)
Solubility
H2O:1 mg/mL (2.52 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.04 mM) ; DMSO:50 mg/mL (126.12 mM)
Smiles
CC (C) S (=O) (=O) NC[C@H] (C) c1ccc (NC (=O) c2cc (F) cc (F) c2) cc1
Molecular Formula
C19H22F2N2O3S
Molecular Weight
396.45
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

(R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide
CAS Number376594-67-1
PubChem CID9843690
IUPAC Name3,5-difluoro-N-[4-[(2R)-1-(propan-2-ylsulfonylamino)propan-2-yl]phenyl]benzamide
Molecular FormulaC19H22F2N2O3S
Molecular Weight396.5
XLogP3.5
Topological Polar Surface Area83.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count27
Formal Charge0
Complexity576
SMILES
C[C@@H](CNS(=O)(=O)C(C)C)C1=CC=C(C=C1)NC(=O)C2=CC(=CC(=C2)F)F
InChI
InChI=1S/C19H22F2N2O3S/c1-12(2)27(25,26)22-11-13(3)14-4-6-18(7-5-14)23-19(24)15-8-16(20)10-17(21)9-15/h4-10,12-13,22H,11H2,1-3H3,(H,23,24)/t13-/m0/s1
InChIKey
ACOXQYLJOQAHST-ZDUSSCGKSA-N
Chemical Structure
2D Structure
2D structure of (R)-3,5-difluoro-N-(4-(1-(1-methylethylsulfonamido)propan-2-yl)phenyl)benzamide
CAS: 376594-67-1
CID: 9843690
Formula: C19H22F2N2O3S
MW: 396.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight396.5
XLogP33.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass396.13192007
Monoisotopic Mass396.13192007
Topological Polar Surface Area83.7 Ų
Heavy Atom Count27
Formal Charge0
Complexity576
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
TQ0289-01LY450108
A12425-50LY450108 50mg
A12425-100LY450108 100mg
A12425-25LY450108 25mg
A12425-10LY450108 10mg
A12425-2LY450108 2mg
A12425-200LY450108 200mg
A12425-5LY450108 5mg
A12425-10mM-DLY450108 10mM * 1mL in DMSO

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