Products for Research Use Only
RegisterLogin

N6022

CAT: 0013-GTR19164304-01Size: 1 gDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19164304-01Size:1 g
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
A potent and reversible S-Nitrosoglutathione reductase (GSNOR) inhibitor with IC50 of 20 nM; reduces bronchoconstriction and pulmonary inflammation in a mouse model of asthma and demonstrates an acceptable safety profile. Asthma Phase 2 Clinical (In Vitro) :N6022 shows concentration-dependent binding to rat plasma proteins. N6022 has more effect on ATP at lower drug concentrations (20 μM) than on GSH. N6022 binds in the GSNO substrate binding pocket like a competitive inhibitor with an IC50 of 8 nM and a Ki of 2.5 nM. N6022 is uncompetitive with cofactors NAD+ and NADH. (In Vivo) :N6022 (50 mg/kg) -treated rats show a slight increase in the incidence of granulomas. In serum, N6022 remains in solution up to 5 mg/mL.
CAS Number
1208315-24-5
Product Name Alternative
N 6022 | N-6022
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 46 mg/mL
Smiles
O=C (O) CCC1=CC=C (C2=CC=C (N3C=CN=C3) C=C2) N1C4=CC=C (C (N) =O) C=C4C
Molecular Formula
C24H22N4O3
Molecular Weight
414.4565
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrrole-2-propanoic acid, 1-[4- (aminocarbonyl) -2-methylphenyl]-5-[4- (1H-imidazol-1-yl) phenyl]-

Alternative Products

CatalogName
B1111-5.1N6022
A13046-10N6022 10mg
A13046-5N6022 5mg
A13046-100N6022 100mg
A13046-50N6022 50mg

Popular Products