Products for Research Use Only

StemRegenin 1 (SR1)

CAT: 0013-GTR19164249-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164249-01Size:500 mg
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Description
StemRegenin 1 is an aryl hydrocarbon receptor (AhR) inhibitor with IC50 of 127 nM in a cell-free assay. (In Vitro) :StemRegenin 1 (SR1) acts by antagonizing the aryl hydrocarbon receptor (AhR) . StemRegenin 1 increases the number of CD34+ cells after 5 to 7 days with an EC50 of ~120 nM. StemRegenin 1 inhibits photoaffinity ligand (PAL) binding (IC50=40 nM) These results support the conclusion that StemRegenin 1 -induced CD34+ cell expansion is mediated through direct binding and inhibition of the AhR. An aryl hydrocarbon receptor antagonist, StemRegenin 1 (SR1), robustly promotes ex vivo expansion of human CD34+ cells. StemRegenin 1 treatment accelerates the proliferation of CD34+ cells and decreases the expression levels of VentX.
CAS Number
1227633-49-9
Product Name Alternative
SR1
Purity
>98% (HPLC)
Solubility
DMSO: 86 mg/mL (200.21 mM)
Smiles
OC1=CC=C (CCNC2=C3N=CN (C (C) C) C3=NC (C4=CSC5=CC=CC=C54) =N2) C=C1
Molecular Formula
C24H23N5OS
Molecular Weight
429.54
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-[2-[[2-benzo[b]thien-3-yl-9- (1-methylethyl) -9H-purin-6-yl]amino]ethyl]-phenol