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URMC-099

CAT: 0013-GTR19164236-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164236-01Size:200 mg
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Description
URMC-099 is a potent, orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3 (MLK3) with IC50 of 14 nM; shows >90% inhibition against 111 kinases in a panel of 442 kinases at 1 uM; URMC-099 likely functions in HIV-1 associated neurocognitive disorders (HAND) preclinical models by inhibiting multiple kinase pathways, including MLK3 and LRRK2 (IC50=11 nM) ; inhibits LPS-induced TNFα release in microglial cells, HIV-1 Tat-induced release of cytokines in human monocytes and up-regulation of phospho-JNK in Tat-injected brains of mice.
CAS Number
1229582-33-5
Product Name Alternative
URMC099
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 33 mg/mL
Smiles
CN1CCN (CC2=CC=C (C3=CN=C (NC=C4C5=CC6=C (NC=C6) C=C5) C4=C3) C=C2) CC1
Molecular Formula
C27H27N5
Molecular Weight
421.5368
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrrolo[2,3-b]pyridine, 3- (1H-indol-5-yl) -5-[4-[ (4-methyl-1-piperazinyl) methyl]phenyl]-

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B4877-5.1URMC-099
FU170951-01URMC 099

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