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Clofarabine

CAT: 0013-GTR19164223-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19164223-01Size:1 g
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Description
Clofarabine (Clolar; Clofarex) inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase. (In Vitro) :Clofarabine potently inhibits DNA synthesis. Clofarabine demonstrates strong in vitro growth inhibition and cytotoxic activity (IC50 values=0.028-0.29 μM) in a wide variety of leukaemia and solid tumour cell lines.Clofarabine (0.01-0.1 μM) inhibits proliferation of NB4 cells, which may be related with the down-regulation of Bcl-2 and induction of apoptosis. (In Vivo) :Clofarabine (330 mg/kg, after a 7-day treatment) causes the death of mice. Higher mortality rates were observed in daytime treatment groups, while more animals survived in night treatment groups. Significant differences of LD50 are found at various time points especially at 12:00 noon and 12:00 midnight.
CAS Number
123318-82-1
Product Name Alternative
Clolar | Evoltra
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 60 mg/mL (197.57 mM)
Smiles
O[C@H]1[C@H] (CO) O[C@@H] (N2C=NC3=C (N) N=C (Cl) N=C23) [C@@H]1F
Molecular Formula
C10H11ClFN5O3
Molecular Weight
303.68
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2S,3S,4R,5R) -5- (6-amino-2-chloro-9H-purin-9-yl) -4-fluoro-2- (hydroxymethyl) tetrahydrofuran-3-ol

Alternative Products

CatalogName
A1412-5.1Clofarabine
469352-01α-Clofarabine

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