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A-1155463

CAT: 0013-GTR19164208-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164208-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A-1155463 is a highly potent and selective BCL-XL inhibitor (Ki=10 pM) ; shows >1000-fold weaker binding to BCL-2, BCL-W (Ki =19 nM) and MCL-1 (Ki >440 nM) ; inhibits H146 SCLC xenograft tumor growth in vivo. (In Vitro) :A-1155463 shows picomolar binding affinity to BCL-XL (Ki<0.01 nM), and >1000-fold weaker binding to BCL-2 (Ki= 80 nM) and related proteins BCL-W (Ki= 19 nM) and MCL-1 (Ki> 440 nM) . A-1155463 demonstrates strong growth inhibition of over half of the colorectal cell lines as defined by EC50 values ≤0.5 μM in the presence of 10 % FBS. (In Vivo) :A-1155463 caused a mechanism-based and reversible thrombocytopenia in mice and inhibited H146 small cell lung cancer xenograft tumor growth in vivo following multiple doses.
CAS Number
1235034-55-5
Product Name Alternative
A1155463 | A 1155463
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 31 mg/mL
Smiles
O=C (C1=C (CCCOC2=CC=C (C#CCN (C) C) C=C2F) SC (N3CC4=C (C=CC=C4C (NC5=NC6=CC=CC=C6S5) =O) CC3) =N1) O
Molecular Formula
C35H32FN5O4S2
Molecular Weight
669.7881
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-Thiazolecarboxylic acid, 2-[8-[ (2-benzothiazolylamino) carbonyl]-3,4-dihydro-2 (1H) -isoquinolinyl]-5-[3-[4-[3- (dimethylamino) -1-propyn-1-yl]-2-fluorophenoxy]propyl]-

Alternative Products

CatalogName
B6163-25A-1155463
440627-01A-1155463 Hydrochloride
S7800-100mgA-1155463 Dihydrochloride
A16112-25A-1155463 25mg
A16112-2A-1155463 2mg

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