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Vinorelbine ditartrate

CAT: 0013-GTR19164173-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164173-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vinorelbine (KW-2307) is a vinca alkaloid chemotherapy agent that inhibits cancer cell mitosis through interaction with tubulin, inhibits HeLa cell proliferation with IC50 of 1.25 nM; induces Hela mitotic block at the metaphase/anaphase transition with IC50 of 3.8 nM, blocks cells exhibited aberrant spindles, consistent with induction of block by suppression of microtubule dynamics.Chemotherapeutic Agents Approved (In Vitro) :Vinorelbine (0.5-5 nM) inhibits cell proliferation by 50% (IC50) at concentrations of 1.25 nM. At concentration of 8 nM vinorelbine, no cells are in anaphase. Vinorelbine time-dependently induces the p53 and p21WAFI/CIP1 expression in androgen-dependent (AD) and- independent (AI) prostate cancer cell lines. Vinorelbine stimulates reporter genes in a concentration-dependent manner. (In Vivo) :After vinorelbine treatment, the first neutropenicepisode occurred after the first (4 dogs), second (1), or sixth (1) vinorelbine treatment in the dogs. Vinorelbine is tolerated at a weekly interval in tumor-bearing cats, with an MTD of 11.5 mg/m2.
CAS Number
125317-39-7
Product Name Alternative
KW-2307 | Nor-5'-anhydrovinblastine ditartrate
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 46 mg/mL
Smiles
CCC1=CC2CC (C3=C (CN (C2) C1) C4=CC=CC=C4N3) (C5=C (C=C6C (=C5) C78CCN9C7C (C=CC9) (C (C (C8N6C) (C (=O) OC) O) OC (=O) C) CC) OC) C (=O) OC.C (C (C (=O) O) O) (C (=O) O) O.C (C (C (=O) O) O) (C (=O) O) O
Molecular Formula
C53H66N4O20
Molecular Weight
1079.106
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Aspidospermidine-3-carboxylic acid, 4- (acetyloxy) -6,7-didehydro-15-[ (2R,6R,8S) -4-ethyl-1,3,6,7,8,9-hexahydro-8- (methoxycarbonyl) -2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α) -, (2R,3R) -2,3-dih

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