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Alectinib

CAT: 0013-GTR19164164-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19164164-01Size:1 g
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Description
A potent, selective ALK inhibitor with IC50 of 1.9 nM; shows high selectivity versus KDR, KIT and MET (IC50>1,400 nM) ; exhibits anti-proliferative activity against NPM-ALK-positive cellline KARPAS-299 with IC50 of 3 nM; also inhibits mutant ALK F1174L and R1275Q with IC50 of 1 nM and 3.5 nM respectively; orally active.Lung Cancer Approved (In Vitro) :Alectinib (0-1000 nM; 2 hours; NCI-H2228 cells) treatment could prevent autophosphorylation of ALK in NCI-H2228 cells expressing EML4-ALK, and it also resulted in substantial suppression of phosphorylation of STAT3 and AKT.Alectinib (0-1000 nM; 5 days; HCC827, A549, or NCIH522 cells) treatment reduces cell activity in a dose-dependent manner. (In Vivo) :Alectinib (0.2-20 mg/kg; oral administration; once daily; for 11 days; SCID or nude mice bearing NCI-H2228 cells) treatment can result in dose-dependent tumor growth inhibition (EC50 of 0.46 mg/kg) and tumor regression. At any dose level, no differences in body weight or gross signs of toxicity are observed.
CAS Number
1256580-46-7
Product Name Alternative
CH5424802 | AF-802 | CH 5424802 | AF802 | AF 802
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 6.2 mg/mL (Need warming)
Smiles
CCC1=C (C=C2C (=C1) C (=O) C1=C (NC3=C1C=CC (=C3) C#N) C2 (C) C) N1CCC (CC1) N1CCOCC1
Molecular Formula
C30H34N4O2
Molecular Weight
482.6165
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5H-Benzo[b]carbazole-3-carbonitrile, 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4- (4-morpholinyl) -1-piperidinyl]-11-oxo-

Alternative Products

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C08838-1gAlectinib
A4649-25Alectinib Hydrochloride
TMID-0073-01Alectinib-d8
ENZ-CHM213-0200Alectinib . hydrochloride
HY-13011S1Alectinib-d6
HY-13011A-01Alectinib (Hydrochloride)

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