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ABT-199

CAT: 0013-GTR19164162-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164162-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Venetoclax (ABT-199, GDC-0199) is a Bcl-2-selective inhibitor with Ki of 4800-fold more selective versus Bcl-xL and Bcl-w, and no activity to Mcl-1. Phase 3. (In Vitro) :Venetoclax (ABT-199) potently kills FL5.12-BCL-2 cells (EC50=4 nM), Venetoclax (ABT-199) shows much weaker activity against FL5.12-BCL-XL cells (EC50=261 nM) . ABT-199 also shows selectivity in cellular mammalian two-hybrid assays, where it disrupts BCL-2-BIM complexes (EC50=3 nM) but is much less effective against BCL-XL-BCL-XS (EC50=2.2 μM) or MCL-1-NOXA complexes. (In Vivo) :After a single oral dose of 12.5 mg per kg body weight in xenografts derived from RS4;11 cells (ALL), Venetoclax (ABT-199) causes a maximal tumor growth inhibition (TGImax) of 47% (P<0.001) and tumor growth delay (TGD) of 26% (P<0.05) .Treatment of established xenografted (a mouse xenograft model of the T-ALL cell line LOUCY) tumors with Venetoclax (ABT-199) 100 mg/kg for 4 days results in a significant reduction of leukemic burden.
CAS Number
1257044-40-8
Product Name Alternative
GDC-0199
Purity
>98% (HPLC)
Solubility
DMSO: 100 mg/mL warmed (115.14 mM)
Smiles
O=C (NS (=O) (C1=CC=C (NCC2CCOCC2) C ([N+] ([O-]) =O) =C1) =O) C3=CC=C (N4CCN (CC5=C (C6=CC=C (Cl) C=C6) CC (C) (C) CC5) CC4) C=C3OC7=CN=C (NC=C8) C8=C7
Molecular Formula
C45H50ClN7O7S
Molecular Weight
868.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4- (4-{[2- (4-chlorophenyl) -4,4-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl) -N- ({3-nitro-4-[ (tetrahydro-2H-pyran-4-ylmethyl) amino]phenyl}sulfonyl) -2- (1H-pyrrolo[2,3-b]pyridin-5-yloxy) benzamide

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