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Spautin-1 (b)

CAT: 0013-GTR19164141-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164141-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Spautin-1 is a potent, small molecule inhibitor of autophagy with IC50 of 0.74 uM, inhibits USP10 and USP13 with IC50 of 0.6-0.7 uM, but not USP14; promotes cell death under starvation condition and inhibits autophagic cell death, selectively promotes the degradation of Vps34 complexes, reduces the levels of PtdIns3P in cells, but is not a direct inhibitor of class III PI3 kinase activity; promotes the degradation of p53 via inhibition of USP10, which can be inhibited in the presence of MG132; sensitizes ovarian cancer cells to cisplatin and PARP inhibitor (olaparib) .
CAS Number
1262888-28-7
Product Name Alternative
Spautin1
Purity
>98% (HPLC)
Solubility
DMSO: 27.1 mg/mL (100 mM) (< 1 mg/ml refers to the product slightly soluble or insoluble)
Smiles
FC1=CC=C (CNC2=C3C=C (F) C=CC3=NC=N2) C=C1
Molecular Formula
C15H11F2N3
Molecular Weight
271.271
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-fluoro-N-[ (4-fluorophenyl) methyl]-4-quinazolinamine

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