Mupirocin

Mupirocin (BRL-4910A) is an antibiotic of the monoxycarbolic acid class; effective against Gram-positive bacteria, including MRSA. (In Vitro) :Mupirocin (BRL-4910A, Pseudomonic acid) (0-100 μM; 48 h) shows antibacterial effect against staphylococci, streptococci and certain gram-negative bacteria, with MIC values range from 0.06-0.25 μg/mL (MIC50 =0.12 μg/mL, MIC90 =0.25 μg/mL) .Mupirocin is highly bound (95% bound) to human serum protein, thus results in activity inhibition in the presence of human serum.Mupirocin apparently exerts its antimicrobial activity by reversibly inhibiting isoleucyl-transfer RNA, thereby inhibiting bacterial protein and RNA synthesis.Mupirocin (2% ointment) reduces pro-inflammatory cytokines IL-1β and IL-17 level, decreases tumor necrosis factor-alpha (TNF-α) expression, and increases the leavel of vascular endothelial growth factor (VEGF) .Mupirocin inhibits MS (S. epidermidis ATCC 12228), MR (S. epidermidis (Se56-99) ), and VIR (S. epidermidis (Se43-98) ) with MICs of 0.25, 1.26, 1.59 mg/L. (In Vivo) :MRSA: Meticillin-resistant Staphylococcus aureusMupirocin (BRL-4910A, Pseudomonic acid) is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A.Mupirocin (2% ointment; external administration; twice daily; 3-6 d) decreases the total bacterial loads in the skin lesions with either topical treatment.Mupirocin (2% ointment; external administration; 4 d) alleviates MRSA-infected pressure ulcers in mice.Mupirocin (100 mg/mL; s.c.; 7 d) exerts prevention efficacy against vascular prosthetic graft infection due to Staphylococcus epidermidis.

12650-69-0

BRL 4910A

Pharmacology & Drug Discovery

>98% (HPLC)

Ethanol: 100 mg/mL (199.75 mM) ; Water: 46 mg/mL warmed (91.88 mM) ; DMSO: 100 mg/mL warmed (199.75 mM)

O=C (O) CCCCCCCCOC (/C=C (C) /C[C@@H]1OC[C@H] (C[C@@H]2O[C@H]2[C@H] ([C@@H] (O) C) C) [C@@H] (O) [C@H]1O) =O

C26H44O9

500.64

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.