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Hydroxyurea

CAT: 0013-GTR19164127-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164127-01Size:500 mg
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Description
Hydroxyurea is an antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase. (In Vitro) :Hydroxyurea is used in a number of myeloproliferative, neoplastic, HIV, and non-hematological diseases. Treatment of cells in primary culture with 30 μM hydroxyurea for 96 hours significantly increases the fractional HbF content. The Gγ: Aγ-globin mRNA is induced 0.30- to 8-fold in vitro. Hydroxyurea has been shown to block HIV-1 reverse transcription and/or replication in quiescent peripheral blood mononuclear cells and macrophages. (In Vivo) :Hydroxyurea therapy producs consistent reductions in WBC and ANC without improvement in anemia over 17 weeks. Hydroxyurea at 50mg/kg produces a reduced white blood cell count, absolute neutrophil count and no improvement in anemia compared to vehicle treated sickle cell mice.
CAS Number
127-07-1
Product Name Alternative
NCI C04831 | NSC 32065
Purity
>98% (HPLC)
Solubility
Water: 15 mg/mL (197.23 mM) ; DMSO: 15 mg/mL (197.23 mM)
Smiles
O=C (N) NO
Molecular Formula
CH4N2O2
Molecular Weight
76.06
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-hydroxyurea

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