FT-011

CAT: 0013-GTR19164116-01Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19164116-01Size:500 mg

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Description

A novel anti-fibrotic agent that prevents TGF-beta-stimulated production of collagen in cultured renal mesangial cells (55-70% inhibition at 30 uM) ; inhibits both TGF-β1 and PDGF-BB induced collagen production as well as PDGF-BB-mediated mesangial proliferation, attenuates the decline in GFR, proteinuria and glomerulosclerosis in a robust model of non-diabetic kidney disease; attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy. (In Vivo) :FT011 (100 mg/kg b.i.d., p.o., for 4 weeks) improves the cardiac function and and myocardial remodeling in myocardial infarction rats.

CAS Number

1001288-58-9

Product Name Alternative

FT011 | SHP-627

Purity

>98% (HPLC)

Solubility

DMSO: ≥ 29 mg/mL

Smiles

O=C (O) C1=CC=CC=C1NC (/C=C/C2=CC=C (OCC#C) C (OC) =C2) =O

Molecular Formula

C20H17NO5

Molecular Weight

351.3527

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

Benzoic acid, 2-[[ (2E) -3-[3-methoxy-4- (2-propyn-1-yloxy) phenyl]-1-oxo-2-propen-1-yl]amino]-

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