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Piceatannol

CAT: 0013-GTR19164097-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19164097-01Size:1 g
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Description
Anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56lck and syk protein tyrosine kinases and inhibits TNF-induced NF-κB activation and gene expression. Synthesis results from conversion of resveratrol by cytochrome P450 1B1. (In Vitro) :Piceatannol is a resveratrol metabolite.SYK inhibitor Piceatannol (3.125, 6.25, 12.5, 25, and 50 μM; 72 hours) inhibits cell growth of six diffuse large B cell lymphomas (DLBCL) cell lines (SUDHL-6, U2392, DOHH2, Karpas 422, VAL, OCI Ly19) with IC50s of 18 μM, 25 μM, 37 μM, 48 μM, >50 μM and >50 μM, respectively. (In Vivo) :Piceatannol (10, 20, and 40 mg/kg) inhibits the pulmonary edema and reduces the infiltration of inflammatory cells induced by lipopolysaccharide.Piceatannol (10, 20, and 40 mg/kg) alleviates the myeloperoxidase activity and inhibits the production of iNOS and COX-2 expressions in lung tissuesinduced bylipopolysaccharide.Piceatannol (10, 20, and 40 mg/kg; intraperitoneally 1 h) treatment alleviates inflammatory response by inhibiting the activation of TLR/NF-κB signaling pathway in lung tissues during acute lung injury (ALI) induced by LPS.
CAS Number
10083-24-6
Product Name Alternative
Astringenin | trans-Picetannol | trans-3,3',4,5'-Tetrahydroxystilbene
Purity
>98% (HPLC)
Solubility
Ethanol: 48 mg/mL (196.52 mM) ; DMSO: 48 mg/mL (196.52 mM)
Smiles
C1 (c (ccc (\C=C\c2cc (O) cc (c2) O) c1) O) O
Molecular Formula
C14H12O4
Molecular Weight
244.24
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(E) -4-[2- (3,5Dihydroxyphenyl) ethenyl]1,2-benzenediol, 3,3′,4,5′-Tetrahydroxy-trans-stilbene

Alternative Products

CatalogName
N2031-5.1Piceatannol

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