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Glyburide

CAT: 0013-GTR19164059-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164059-01Size:500 mg
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Description
Glibenclamide (Glyburide) is a sulfonylurea compound that modulates insulin production. (In Vitro) :Glibenclamide (Brown adipocytes; 10 μΜ; 1 day) has no effect on adipocyte differentiation. Glibenclamide (Ucp1-2A-GFP brown adipocyte) significantly increases UCP1 expression. Glibenclamide directly binds and blocks the SUR1 subunits of ATP-dependent potassium channels (KATP) and consequently increases insulin secretion from the pancreatic β cells. Glibenclamide interferes with mitochondrial bioenergy by permeating mitochondrial intima with Cl- and promoting mitochondrial net Cl-/K+ cotransport. Glibenclamide induced autophagy inhibits its insulin secretion-improving function in β cells. (In Vivo) :Glibenclamide (2 mg/kg; p.o.) increases of insulin release and rapid drop of blood glucose level.Glibenclamide (50 μg/kg; p.o.) does not cause significant change, such as body weight or body composition.
CAS Number
10238-21-8
Product Name Alternative
Glyburide | Glibenclamide | Micronase | Diabeta | HB-420 | HB419 | Maninil | Neogluconin
Purity
>98% (HPLC)
Solubility
DMSO: 99mg/ml (200.4 mM) ; Water: <1mg/ml; Ethanol: <1mg/ml
Smiles
COC1=C (C=C (C=C1) Cl) C (=O) NCCC2=CC=C (C=C2) S (=O) (=O) NC (=O) NC3CCCCC3
Molecular Formula
C23H28ClN3O5S
Molecular Weight
494.01
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-chloro-N-[2-[4- (cyclohexylcarbamoylsulfamoyl) phenyl]ethyl]-2-methoxybenzamide

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