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Daptomycin

CAT: 0013-GTR19164037-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164037-01Size:500 mg
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Description
Daptomycin is a novel antibiotic with rapid in vitro bactericidal activity against gram-positive organisms. (In Vitro) :Daptomycin has excellent in-vitro inhibitory and bactericidal activity against nafcillin-susceptible and resistant staphylococci (MIC90 less than or equal to 0.5 mg/L) and against enterococci (MIC90 less than or equal to 2.0 mg/L) . Daptomycin is more active than vancomycin against the majority of isolated tested. With the exception of trimethoprim-sulphamethoxazole, daptomycin is the most active agent in vitro against enterococci, and is the most active against nafcillin-resistant staphylococci. Daptomycin and vancomycin show a marked increase in MIC when the inoculum is increased from 105 to 107 cfu/mL. Daptomycin is effective within a very narrow range of drug concentrations (from 0.125 to 2.0 tLg/mL) and is more active than other agents tested against S. faecalis. Daptomycin inhibits the formation of these nucleotide-linked intermediates. (In Vivo) :At a dose of 10 mg/kg given twice daily, daptomycin reduces the number of organisms per kidney significantly compared with that in infected untreated controls within 48 h after the initiation of therapy. At 20 mg/kg given once a day, daptomycin is less effective but reduces colony counts significantly after 4 days of therapy, and its activity is comparable to that of vancomycin or vancomycin-gentamicin given twice daily.
CAS Number
103060-53-3
Product Name Alternative
Cubicin | LY146032
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: 100 mg/mL (61.7 mM)
Smiles
O=C1NCC (N[C@@H] (CCCN) C (N[C@@H] (CC (O) =O) C (N[C@H] (C) C (N[C@@H] (CC (O) =O) C (NCC (N[C@H] (CO) C (N[C@@H] ([C@H] (C) CC (O) =O) C (N[C@@H] (CC (C2=CC=CC=C2N) =O) C (OC (C) C1NC ([C@@H] (NC ([C@@H] (NC ([C@@H] (NC (CCCCCCCCC) =O) CC3=CNC4=C3C=CC=C4) =O) CC (N) =O) =O) CC (O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O) =O
Molecular Formula
C72H101N17O26
Molecular Weight
1620.68
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,2'- ((3S,6S,9R,15S,18R,21S,24S) -30- ((S) -2- ((S) -4-amino-2- ((S) -2-decanamido-3- (1H-indol-3-yl) propanamido) -4-oxobutanamido) -3-carboxypropanamido) -3- (2- (2-aminophenyl) -2-oxoethyl) -24- (3-aminopropyl) -6- ((R) -1-carboxypropan-2-yl) -9- (hydroxymethyl) -18,31-dimethyl-2,5,8,11,14,17,20,23,26,29-decaoxo-1-oxa-4,7,10,13,16,19,22,25,28-nonaazacyclohentriacontane-15,21-diyl) diacetic acid

Alternative Products

CatalogName
A1206-5.1Daptomycin

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