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Gimeracil

CAT: 0013-GTR19164008-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19164008-01Size:1 g
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Description
An inhibitor of dihydropyrimidine dehydrogenase, degrades pyrimidine including 5-fluorouracil in the blood; inhibits homologous recombination. Chemotherapeutic Agents Approved (In Vitro) :Gimeracil reduces the frequency of neo-positive clones. Additionally, it sensitized the cells in S-phase more than in G0/G1.Gimeracil may enhance the efficacy of radiotherapy through the suppression of HR-mediated DNA repair pathways.Gimeracil pretreatment significantly restrains the formation of radiation-induced foci of Rad51 and RPA, whereas it increased the number of foci of Nbs1, Mre11, Rad50, and FancD2. (In Vivo) :Gimeracil (2.5-25 mg/kg, orally) may inhibit the rapid repair of X-ray-induced DNA damage in tumors.
CAS Number
103766-25-2
Product Name Alternative
Gimestat
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 29 mg/mL
Smiles
O=C1C=C (O) NC=C1Cl
Molecular Formula
C5H4ClNO2
Molecular Weight
145.5438
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2 (1H) -Pyridinone, 5-chloro-4-hydroxy-

Alternative Products

CatalogName
HY-17469-01Gimeracil

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