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Granisetron hydrochloride

CAT: 0013-GTR19163955-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163955-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Granisetron Hcl (BRL 43694A) is a serotonin 5-HT3 receptor antagonist used as an antiemetic to treat nausea and vomiting following chemotherapy. IC50 Value: 17uM (GR reduced 5-HT-evoked contractions) (In Vitro) :In rat forestomach GR reduced 5-HT-evoked contractions at IC50 17 /- 6 uM. In isolated rabbit heart, GR 0.003-0.03 nM dose-dependently reduced s-HT tachycardia; at high levels GR reduced submaximal and maximal responses to 5-HT. (In Vivo) :Leukocyte accumulation was dose-dependently inhibited by granisetron both at 6 and 72 h after induction of inflammation. Granisetron increased PGE (2) level at a lower dose (50 microg/pouch) but higher doses (100 and 200 microg/pouch) inhibited the release. At the same time, TNFalpha production was decreased by the lower dose and increased by higher doses of granisetron in a reciprocal fashion. The GTDS displayed non-inferiority to oral granisetron: complete control was achieved by 60% of patients in the GTDS group, and 65% in the oral granisetron group (treatment difference, -5%; 95% confidence interval, -13-3) . Both treatments were well tolerated, the most common adverse event being constipation.
CAS Number
107007-99-8
Product Name Alternative
BRL 43694
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 1 mg/mL (2.86 mM) ; Water: 70 mg/mL (200.64 mM) ; DMSO: 1 mg/mL (2.86 mM)
Smiles
Cl.CN1N=C (C (=O) NC2CC3CCCC (C2) N3C) C2=CC=CC=C12
Molecular Formula
C18H25ClN4O
Molecular Weight
348.87
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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