I-BET151

CAT: 0013-GTR19163905-01Size: 1 gDry Ice: NoHazardous: No

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CAT#:0013-GTR19163905-01Size:1 g

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Description

I-BET151 (GSK1210151A) is a potent, selective BET bromodomain inhibitor with IC50 of 0.5, 0.25 and 0.79 uM for BRD2, BRD3 and BRD4 in FP assays, shows no effect on the 23 other bromodomain proteins including MLL; demonstrates potent efficacy against cell lines harbouring different MLL-fusions (MOLM13 cell IC50=120 nM, MV4:11 cell IC50=26 nM), induices early cell cycle arrest and apoptosis, selectively abrogates BRD3/4 recruitment to chromatin; shows significant therapeutic value and survival benefit in mouse models of murine MLL-AF9 and human MLL-AF4 leukaemia.

CAS Number

1300031-49-5

Product Name Alternative

GSK1210151A | I-BET 151 | GSK-1210151A

Purity

>98% (HPLC)

Solubility

10 mM in DMSO

Smiles

O=C (N1[C@@H] (C2=NC=CC=C2) C) NC3=C1C4=CC (OC) =C (C5=C (C) ON=C5C) C=C4N=C3

Molecular Formula

C23H21N5O3

Molecular Weight

415.4445

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

2H-Imidazo[4,5-c]quinolin-2-one, 7- (3,5-dimethyl-4-isoxazolyl) -1,3-dihydro-8-methoxy-1-[ (1R) -1- (2-pyridinyl) ethyl]-

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Alternative Products

Catalog	Name
HY-13235-01	I-BET151
B1500-50	I-BET151 (GSK1210151A)
T22845-01	I-BET151 dihydrochloride
HY-110106-01	I-BET151 (dihydrochloride)
MBS131026-01	I-BET151(GSK1210151A)

I-BET151

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