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Dorzolamide hydrochloride

CAT: 0013-GTR19163888-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163888-01Size:1 g
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Description
Dorzolamide Hcl (L671152 Hcl; MK507 Hcl) is an anti-glaucoma agent, which is a carbonic anhydrase inhibitor. (In Vitro) :Component A, caused by an inward flux of CO2 and its subsequent hydration by CA-II, is blocked by Dorzolamide in a dose-dependent manner with an 50% inhibitory concentration IC50 of 2.4 μM (95% confidence interval: 0.5-10.85 μM) . (In Vivo) :Dorzolamide (3, 10, or 30 mg/kg/day, ip) synergized mitomycin C exhibits anti-tumor activity in EAC solid tumor models. Dorzolamide produces a dose-dependent decrease in the calculated ratio (relative value of 57.3±1, 25.5±1.8, and 24.3± 0.7 %, respectively) .
CAS Number
130693-82-2
Product Name Alternative
L-671,152 | MK-507
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: 14 mg/mL (38.79 mM)
Smiles
O=S (C (S1) =CC ([C@@H] (NCC) C[C@@H]2C) =C1S2 (=O) =O) (N) =O.[H]Cl
Molecular Formula
C10H17ClN2O4S3
Molecular Weight
360.9
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(4S,6S) -4- (ethylamino) -6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide hydrochloride

Chemical Information

Dorzolamide Hydrochloride

Dorzolamide Hydrochloride is the hydrochloride salt form of dorzolamide, an inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions. Distributed throughout many cells and tissues, various carbonic anhydrases play important roles in mineral and metabolic homeostasis. (NCI04)

CAS Number130693-82-2
PubChem CID6918132
IUPAC Name(4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide;hydrochloride
Molecular FormulaC10H17ClN2O4S3
Molecular Weight360.9
Topological Polar Surface Area151
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity534
SMILES
CCN[C@H]1C[C@@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.Cl
InChI
InChI=1S/C10H16N2O4S3.ClH/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16;/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16);1H/t6-,8-;/m0./s1
InChIKey
OSRUSFPMRGDLAG-QMGYSKNISA-N
Chemical Structure
2D Structure
2D structure of Dorzolamide Hydrochloride
CAS: 130693-82-2
CID: 6918132
Formula: C10H17ClN2O4S3
MW: 360.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight360.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass360.0038982
Monoisotopic Mass360.0038982
Topological Polar Surface Area151 Ų
Heavy Atom Count20
Formal Charge0
Complexity534
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
TRC-D535100-50MGDorzolamide Hydrochloride
HY-B0109A-01Dorzolamide (hydrochloride)
HY-B0109ASDorzolamide-d3 (hydrochloride)
446216-01Desaminosulfonyl Dorzolamide Hydrochloride
sc-495898Ent-Dorzolamide hydrochloride
HY-B0109AR-01Dorzolamide (hydrochloride) (Standard)
HY-B0109AS1-01Dorzolamide-d5 (hydrochloride)
TRC-D535120-5MGrac-trans Dorzolamide Hydrochloride
sc-505114N-Deethyl Dorzolamide Hydrochloride
TRC-D535115-100MGrac-cis Dorzolamide Hydrochloride

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