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Olanzapine

CAT: 0013-GTR19163847-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163847-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Olanzapine is an atypical antipsychotic, approved by the FDA in 1996. Olanzapine is manufactured and marketed by the pharmaceutical company Eli Lilly and Company, whose patent for olanzapine proper ends in 2011. (In Vitro) :Olanzapine binds weakly to GABAA, Benzodiazepine (BZD), and β-adrenergic receptors (Ki>10 μM) .Olanzapine induces autophagy in human SH-SY5Y neuronal cell line.Olanzapine (1-100 μM for 144 h under serum starvation) results in a marked anti-proliferative effect in glioblastoma cell lines as well as glioma stem-like cells.Olanzapine also enhances Temozolomide’s anti-tumor activity in glioblastoma cell lines.Olanzapine induces apoptosis and necrosis in glioblastoma cell lines. (In Vivo) :Olanzapine (0.75, 1.5 and 3 mg/kg) evaluates body weight and periuterine fat mass, as well as insulin, non-esterified fatty acids, triglycerides, and glucose levels in mice.
CAS Number
132539-06-1
Product Name Alternative
LY170053
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 9 mg/mL (28.8 mM) ; DMSO: 63 mg/mL (201.63 mM)
Smiles
CN1CCN (C2=C (C=C (C) S3) C3=NC4=CC=CC=C4N2) CC1
Molecular Formula
C17H20N4S
Molecular Weight
312.44
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-methyl-4- (4-methylpiperazin-1-yl) -5H-thieno[3,2-c][1,5]benzodiazepine

Alternative Products

CatalogName
B2240-5.1Olanzapine

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