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Trichlormethiazide

CAT: 0013-GTR19163821-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163821-01Size:500 mg
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Description
Trichlormethiazide is a thiazide diuretic with properties similar to those of hydrochlorothiazide. It is usually administered for the treatment of oedema (including that which is associated with heart failure, hepatic cirrhosis and corticosteroid therapy) and hypertension. (In Vivo) :Trichlormethiazide (1 mg/kg; p.o.; once) increases urinary volume, sodium and potassium excretion in rats.Trichlormethiazide (10 mg/kg, i.v.; daily for 5 days) significantly reduces mean arterial pressure (MAP) within 24 h in high salt intake (HS) rats receiving angiotensin II, but does not affect MAP in any other group.
CAS Number
133-67-5
Product Name Alternative
BRN 0629145 | Trichlormethiazide | Diurazida | Diurese
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 54 mg/mL (141.85 mM)
Smiles
O=S (C1=C (Cl) C=C (C2=C1) NC (C (Cl) Cl) NS2 (=O) =O) (N) =O
Molecular Formula
C8H8Cl3N3O4S2
Molecular Weight
380.66
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-chloro-3- (dichloromethyl) -3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide

Chemical Information

Trichlormethiazide

Trichlormethiazide is a benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. It has a role as a diuretic and an antihypertensive agent. It is a benzothiadiazine and a sulfonamide antibiotic.

CAS Number133-67-5
PubChem CID5560
IUPAC Name6-chloro-3-(dichloromethyl)-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
Molecular FormulaC8H8Cl3N3O4S2
Molecular Weight380.7
XLogP0.6
Topological Polar Surface Area135
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity571
SMILES
C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)NC(N2)C(Cl)Cl
InChI
InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
InChIKey
LMJSLTNSBFUCMU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Trichlormethiazide
CAS: 133-67-5
CID: 5560
Formula: C8H8Cl3N3O4S2
MW: 380.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight380.7
XLogP30.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count2
Exact Mass378.902181
Monoisotopic Mass378.902181
Topological Polar Surface Area135 Ų
Heavy Atom Count20
Formal Charge0
Complexity571
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B2056-5.1Trichlormethiazide
468053-01Trichlormethiazide-13C6
HY-B0235R-01Trichlormethiazide (Standard)
MBS5804675Trichlormethiazide sodium
HY-B0235ATrichlormethiazide (sodium)

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