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Verinurad

CAT: 0013-GTR19163770-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163770-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A highly potent and specific URAT1 inhibitor with IC50 of 25 nM; displays 200-fold lower affinity for the related URAT1 homologs OAT4 and OAT1; reduces the sUA by up to 60% with a single 40 mg dose in healthy human volunteers, and increases the FEUA in a dose-dependent manner with EC50 of 22 nM; currently in phase 2 trials for the treatment of gout and asymptomatic hyperuricemia.Gout Phase 2 Clinical (In Vitro) :Verinurad inhibits the transport activity of human URAT1 in a dose-dependent manner, at high potency with an IC50 of 25 nM.
CAS Number
1352792-74-5
Product Name Alternative
RDEA-3170
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) (SC1=C (C2=C3C=CC=CC3=C (C#N) C=C2) C=NC=C1) C (O) =O
Molecular Formula
C20H16N2O2S
Molecular Weight
348.4182
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Propanoic acid, 2-[[3- (4-cyano-1-naphthalenyl) -4-pyridinyl]thio]-2-methyl-

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