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Poseltinib

CAT: 0013-GTR19163766-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163766-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Poseltinib (HM-71224, LY-3337641) is a potent and selective, covalent inhibitor of Btk with IC50 of 1.95 nM; also inhibits BMX, TEC, TXK, EGFR in biochemical sense (IC50=0.3-2.5 nM) ; effectively inhibits the phosphorylation of Btk and PLCγ2, and inhibits expression of CD40, CD69, and CD86 by activated primary human B cells with IC50 of 4.2, 4.2, and 7.7 nM, respectively; inhibited the production of TNF-α, IL-6, and IL-1β by human monocytes, and osteoclast formation by human monocytes; ameliorates arthritis in a mouse model.Rheumatoid Arthritis Phase 1 Clinical.
CAS Number
1353552-97-2
Product Name Alternative
HM-71224 | LY-3337641
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 100 mg/mL (212.53 mM)
Smiles
C=CC (NC1=CC=CC (OC2=C (OC=C3) C3=NC (NC4=CC=C (N5CCN (C) CC5) C=C4) =N2) =C1) =O
Molecular Formula
C26H26N6O3
Molecular Weight
470.533
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Propenamide, N-[3-[[2-[[4- (4-methyl-1-piperazinyl) phenyl]amino]furo[3,2-d]pyrimidin-4-yl]oxy]phenyl]-

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BA6302-5.1Poseltinib
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A19450-10Poseltinib (HM71224, LY3337641) 10mg
A19450-5Poseltinib (HM71224, LY3337641) 5mg
A19450-100Poseltinib (HM71224, LY3337641) 100mg
A19450-50Poseltinib (HM71224, LY3337641) 50mg
A19450-1Poseltinib (HM71224, LY3337641) 1mg

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