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G-418 disulfate

CAT: 0013-GTR19163699-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163699-01Size:500 mg
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Description
An aminoglycoside antibiotic similar in structure to gentamicin B1; blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. (In Vitro) :G418 sulfate, an aminoglycoside neomycin analogue, interferes with protein synthesis and has been used extensively for selection of mammalian cell lines that possess neomycin resistance (NR) . The neomycin resistance (neo) gene is frequently used in eukaryotic vectors as a dominant selectable gene. G418 can be covalently bound to asialoorosomucoid (AsOR) to form a conjugate for hepatocyte-specific targeting and toxicity.The human GD3 synthase cDNA was transfected into MDA-MB231 cells, and G-418 bulk selection was used to select cells stably overexpressing the GD3 synthase. An aminoglycoside antibiotic, G418, has been shown to be an inhibitor of many pro- and eukaryotes at concentrations from 1-300 microgram/ml.
CAS Number
108321-42-2
Product Name Alternative
Geneticin sulfate
Purity
>98% (HPLC)
Solubility
H2O: ≥ 30 mg/mL
Smiles
O[C@@H]1[C@H] (O[C@@H]2[C@@H] (O) [C@H] (O[C@H]3O[C@H] (C (O) C) [C@@H] (O) [C@H] (O) [C@H]3N) [C@@H] (N) C[C@H]2N) OC[C@] (O) (C) [C@H]1NC.O=S (O) (O) =O
Molecular Formula
C20H44N4O18S2
Molecular Weight
692.7094
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
D-Streptamine, O-2-amino-2,7-dideoxy-D-glycero-α-D-gluco-heptopyranosyl- (1→4) -O-[3-deoxy-4-C-methyl-3- (methylamino) -β-L-arabinopyranosyl- (1→6) ]-2-deoxy-, sulfate (1:2)

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