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Mizolastine

CAT: 0013-GTR19163690-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19163690-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mizolastine is a histamine H1-receptor antagonist with IC50 of 47 nM used in the treatment of hay fever (seasonal allergic rhinitis), hives and other allergic reactions. (In Vitro) :Mizolastine (1-10000 nM; 0.5-6 h) shows inhibitory effects on VEGF, KC and TNF-α release in mast cells.Mizolastine (0.1 μM; 4 h) significantly reduces VEGF165, VEGF120, TNF-α and KC mRNA expression in mast cells. (In Vivo) :Mizolastine (0.3 mg/kg; p.o.; single daily for 7 days) inhibits production of 5-LOX AA (arachidonic acid) metabolite leukotriene B4 (LTB4), and suppresses expression of 5-LOX, cytosolic PLA2 (cPLA2), 5-LOX-activating protein, and LTB4 receptor mRNA in the AA-induced inflammation model.
CAS Number
108612-45-9
Product Name Alternative
SL 85.0324 | Mistalin | Mistamine | Mizolastina
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: <1 mg/mL warmed (<1 mM) ; Water: <1 mg/mL (<1 mM) ; DMSO: <1 mg/mL (<1 mM)
Smiles
O=C1NC (N (C2CCN (C3=NC4=CC=CC=C4N3CC5=CC=C (F) C=C5) CC2) C) =NC=C1
Molecular Formula
C24H25FN6O
Molecular Weight
432.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- ((1- (1- (p-Fluorobenzyl) -2-benzimidazolyl) -4-piperidyl) methylamino) -4 (3H) -pyrimidinone

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